Author
Luc Muyldermans
Other affiliations: Katholieke Universiteit Leuven, INSEAD
Bio: Luc Muyldermans is an academic researcher from University of Nottingham. The author has contributed to research in topics: Arc routing & Routing (electronic design automation). The author has an hindex of 17, co-authored 27 publications receiving 1319 citations. Previous affiliations of Luc Muyldermans include Katholieke Universiteit Leuven & INSEAD.
Papers
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TL;DR: A new local search algorithm for the capacitated arc routing problem (CARP) is presented that outperforms the existing heuristics for the CARP and often detects an optimal solution within limited computation time.
184 citations
TL;DR: In this article, the role of environmental regulations in inducing innovation and improving performance has been studied in the literature, but there have been no studies in the UK using statistical data, and the authors aim to study the links among regulations, innovation and performance using sector level data.
Abstract: Purpose – The role of environmental regulations in inducing innovation and improving performance has been studied in the literature. However, there have been no studies in the UK using statistical data. This paper aims to study the links among regulations, innovation and performance in the UK using sector level data.Design/methodology/approach – The paper used structural equation modelling to study the links among the three variables simultaneously.Findings – The analysis indicates that environmental regulations in the UK are significant in improving economic performance of the industrial sectors. They also find that, in the short run, environmental regulations negatively influence innovation, and innovation negatively influences economic performance in these sectors.Practical implications – The results have implications both for policy makers and firms in the UK industrial sector. For policy makers, environmental regulations have generally improved economic performance. For firms, the study shows that su...
169 citations
TL;DR: STAR appears to be at least as effective for early coronary recanalization as and significantly more fibrin-specific than accelerated RTPA in patients with evolving myocardial infarction.
Abstract: Background Recombinant staphylokinase (STAR) was shown recently to offer promise for coronary arterial thrombolysis in patients with evolving myocardial infarction. The present multicenter randomized open trial was designed to assess the thrombolytic efficacy, safety, and fibrin specificity of STAR relative to accelerated alteplase (recombinant tissue-type plasminogen activator [RTPA]). Methods and Results One hundred patients with evolving myocardial infarction of <6 hours’ duration and with ST-segment elevation were allocated to accelerated and weight-adjusted RTPA over 90 minutes (52 patients) or to STAR (the first 25 patients to 10 mg and the next 23 patients to 20 mg given intravenously over 30 minutes). All patients received aspirin and intravenous heparin. The main end points were coronary artery patency and plasma fibrinogen levels at 90 minutes. Thrombolysis in Myocardial Infarction (TIMI) perfusion grade 3 at 90 minutes was achieved in 62% of STAR patients versus 58% of RTPA patients (risk ratio...
147 citations
TL;DR: A heuristic procedure for districting, which partitions the road network into small cycles, then aggregate them into districts in two phases using an approach based on bin packing principles, while in Phase 2 a multi criteria approach is used.
130 citations
TL;DR: This work worked on a project with Hewlett-Packard's remarketing group to unlock the value potential of time-sensitive returns, and used simple operations research flow models to evaluate new design and policy options for the reverse supply chain.
Abstract: Hewlett-Packard (HP) and other companies producing short life-cycle products with rapid value erosion squander the opportunity to profit from returned time-sensitive products when they treat them as a nuisance. Instead of focusing on cost minimization and technical quality, they should recognize returns as a value stream and maximize the revenue from smart and fast disposition, proper refurbishment, and prompt resale through the appropriate channels. We worked on a project with Hewlett-Packard's remarketing group to unlock the value potential of time-sensitive returns. We analyzed data using simple calculations to reveal the major drivers and magnitude of potential value recovery, and we used simple operations research flow models to evaluate new design and policy options for the reverse supply chain. HP benefited from an integrated end-to-end business approach to product returns.
119 citations
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01 May 1981
TL;DR: This chapter discusses Detecting Influential Observations and Outliers, a method for assessing Collinearity, and its applications in medicine and science.
Abstract: 1. Introduction and Overview. 2. Detecting Influential Observations and Outliers. 3. Detecting and Assessing Collinearity. 4. Applications and Remedies. 5. Research Issues and Directions for Extensions. Bibliography. Author Index. Subject Index.
4,948 citations
Posted Content•
TL;DR: A theme of the text is the use of artificial regressions for estimation, reference, and specification testing of nonlinear models, including diagnostic tests for parameter constancy, serial correlation, heteroscedasticity, and other types of mis-specification.
Abstract: Offering a unifying theoretical perspective not readily available in any other text, this innovative guide to econometrics uses simple geometrical arguments to develop students' intuitive understanding of basic and advanced topics, emphasizing throughout the practical applications of modern theory and nonlinear techniques of estimation. One theme of the text is the use of artificial regressions for estimation, reference, and specification testing of nonlinear models, including diagnostic tests for parameter constancy, serial correlation, heteroscedasticity, and other types of mis-specification. Explaining how estimates can be obtained and tests can be carried out, the authors go beyond a mere algebraic description to one that can be easily translated into the commands of a standard econometric software package. Covering an unprecedented range of problems with a consistent emphasis on those that arise in applied work, this accessible and coherent guide to the most vital topics in econometrics today is indispensable for advanced students of econometrics and students of statistics interested in regression and related topics. It will also suit practising econometricians who want to update their skills. Flexibly designed to accommodate a variety of course levels, it offers both complete coverage of the basic material and separate chapters on areas of specialized interest.
4,284 citations
TL;DR: This meta-analysis found that radial access reduced major bleeding and there was a corresponding trend for reduction in ischemic events compared to femoral access, and large randomized trials are needed to confirm the benefit of radial access on death and isChemic events.
1,000 citations
TL;DR: A clear ongoing trend toward equalization of the two procedures, in terms of procedural success, is evident through the years, probably due to technologic progress of materials and increased operator experience.
974 citations