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Author

Luca Sterpone

Other affiliations: Instituto Politécnico Nacional
Bio: Luca Sterpone is an academic researcher from Polytechnic University of Turin. The author has contributed to research in topics: Fault injection & Field-programmable gate array. The author has an hindex of 24, co-authored 222 publications receiving 3125 citations. Previous affiliations of Luca Sterpone include Instituto Politécnico Nacional.


Papers
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Proceedings ArticleDOI
24 May 2010
TL;DR: The framework integrates three strategies independently designed to tackle the problem of SEUs, using an enhanced TMR-based technique, coupled with partial dynamic reconfiguration and a robustness analysis to identify possible TMR failures.
Abstract: This paper presents an enhanced design flow for the implementation of hardened systems on SRAM-based FPGAs, able to cope with the occurrence of Single Event Upsets (SEUs). The framework integrates three strategies independently designed to tackle the problem of SEUs; first a systematic methodology is used to harden the circuit exploiting an enhanced TMR-based technique, coupled with partial dynamic reconfiguration. Then, a robustness analysis is performed to identify possible TMR failures, eventually solved by a specific local re-design of the critical portions of the implementation. We present the overall flow and the benefits of the solution, experimentally evaluated on a realistic circuit.

8 citations

Proceedings ArticleDOI
01 Sep 2016
TL;DR: In this paper, a mapping tool for selectively mitigating radiation-induced single event transient phenomena within the silicon structure of Microsemi RTG4 Radiation hardened Flash-based FPGAs is proposed.
Abstract: This paper proposes a mapping tool for selectively mitigate radiation-induced Single Event Transient phenomena within the silicon structure of Microsemi RTG4 Radiation hardened Flash-based FPGAs. Experimental results on three benchmark circuits demonstrated effective SET mitigation.

8 citations

Proceedings ArticleDOI
22 Jun 2008
TL;DR: A novel design flow able to implement fault tolerant circuits on SRAM-based FPGAs while reducing the performance penalties is presented, based on a placement algorithm ruled by topology heuristics and a routing algorithm driven by a congestion graph able to remove the crossing errors domains.
Abstract: Reconfigurable logic devices such as SRAM-based field programmable gate arrays (FPGAs) are nowadays increasingly popular thanks to their capability of implementing complex circuits with very short development time and for their high versatility in implementing different kind of applications, ranging from signal processing to the networking. The usage of reconfigurable devices in safety critical fields, such as space or avionics, require the adoption of specific fault tolerant techniques, like triple modular redundancy (TMR), in order to protect their functionality against radiation effects. While these techniques allow increasing the protection capability against radiation effects, they introduce several penalties to the design, particularly in terms of performances. In this paper, we present a novel design flow able to implement fault tolerant circuits on SRAM-based FPGAs while reducing the performance penalties. The flow is based on a placement algorithm ruled by topology heuristics and on a routing algorithm driven by a congestion graph able to remove the crossing errors domains. Experimental evaluations performed by means of timing analysis and static analysis on industrial-like case studies demonstrated that the proposed algorithm is able to improve the running frequency up to the 44% versus standard TMR-based techniques while maintaining complete fault tolerance capabilities.

8 citations

Proceedings ArticleDOI
25 Jun 2005
TL;DR: New improvements for an existing evolutionary algorithm, called µGP, able to generate Turing-complete programs are described; these are exploited, along with hardware acceleration techniques, to add content to a qualifying test campaign by automatically generating assembly programs.
Abstract: Checking if microprocessor cores are fully functional at the end of the productive process has become a major issue. Traditional functional approaches are not sufficient when considering modern designs. This paper describes new improvements for an existing evolutionary algorithm, called µGP, able to generate Turing-complete programs; these are exploited, along with hardware acceleration techniques, to add content to a qualifying test campaign by automatically generating assembly programs. The approach is suitable for medium-sized processor cores. The experimental evaluation performed on a SPARCv8 clearly shows the potentiality of the approach, and the effectiveness of the enhancements to the evolutionary core.

8 citations

Journal ArticleDOI
TL;DR: In this paper, a new radiation-hardened-by-design fulladder cell on 45-nm technology is presented, which is hardened against transient errors by selective duplication of sensitive transistors based on a comprehensive radiation-sensitivity analysis.
Abstract: Single event transients (SETs) have become increasingly problematic for modern CMOS circuits due to the continuous scaling of feature sizes and higher operating frequencies. Especially when involving safety-critical or radiation-exposed applications, the circuits must be designed using hardening techniques. In this brief, we present a new radiation-hardened-by-design full-adder cell on 45-nm technology. The proposed design is hardened against transient errors by selective duplication of sensitive transistors based on a comprehensive radiation-sensitivity analysis. Experimental results show a 62% reduction in the SET sensitivity of the proposed design with respect to the unhardened one. Moreover, the proposed hardening technique leads to improvement in performance and power overhead and zero area overhead with respect to the state-of-the-art techniques applied to the unhardened full-adder cell.

8 citations


Cited by
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Journal ArticleDOI
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Abstract: In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

3,690 citations

Journal ArticleDOI
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
Abstract: Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.

2,507 citations

Journal ArticleDOI
16 Mar 2012-Cell
TL;DR: Emerging principles of miRNA regulation of stress signaling pathways are reviewed and applied to the authors' understanding of the roles of miRNAs in disease.

1,491 citations

Journal ArticleDOI
TL;DR: The results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.
Abstract: The shear-responsive transcription factor Kruppel-like factor 2 (KLF2) is a critical regulator of endothelial gene expression patterns induced by atheroprotective flow. As microRNAs (miRNAs) post-transcriptionally control gene expression in many pathogenic and physiological processes, we investigated the regulation of miRNAs by KLF2 in endothelial cells. KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster. Interestingly, miR-143/145 has been shown to control smooth muscle cell (SMC) phenotypes; therefore, we investigated the possibility of transport of these miRNAs between endothelial cells and SMCs. Indeed, extracellular vesicles secreted by KLF2-transduced or shear-stress-stimulated HUVECs are enriched in miR-143/145 and control target gene expression in co-cultured SMCs. Extracellular vesicles derived from KLF2-expressing endothelial cells also reduced atherosclerotic lesion formation in the aorta of ApoE(-/-) mice. Combined, our results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.

1,182 citations

Journal ArticleDOI
TL;DR: The information synthesized is expected to open new avenues for a large scale use of insect products as animal feed, and the levels of Ca and fatty acids in insect meals can be enhanced by manipulation of the substrate on which insects are reared.

1,068 citations