Author
Luca Sterpone
Other affiliations: Instituto Politécnico Nacional
Bio: Luca Sterpone is an academic researcher from Polytechnic University of Turin. The author has contributed to research in topics: Fault injection & Field-programmable gate array. The author has an hindex of 24, co-authored 222 publications receiving 3125 citations. Previous affiliations of Luca Sterpone include Instituto Politécnico Nacional.
Papers published on a yearly basis
Papers
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TL;DR: This comprehensive ISA extension improves performance and fault detection capabilities of software-based approaches at negligible costs in terms of circuit area and can help engineers in designing more efficient and resilient GPU architectures.
4 citations
TL;DR: In this article, a methodology is proposed to emulate and assess the single event effect in configuration memory on 16-nm Ultrascale+ MPSoC. The solution depends on fault injection and fault tree analysis.
4 citations
08 Jul 2007
TL;DR: Experimental results coming from fault injection campaigns on a Reed-Solomon decoder demonstrated that by observing the occurred errors and the correspondent detection module has been possible to reduce the number of detection module, while paying a small reduction of the percentage of SEUs that can be detected.
Abstract: This paper shows how the use of exhaustive fault injection campaigns in conjunction with the analysis of the property of a circuit, allows to improve the efficiency of the checker of self checking circuits. Experimental results coming from fault injection campaigns on a Reed-Solomon decoder demonstrated that by observing the occurred errors and the correspondent detection module has been possible to reduce the number of detection module, while paying a small reduction of the percentage of SEUs that can be detected.
4 citations
TL;DR: A novel method for analyzing the sensitivity with respect to Single Event Latch-up (SEL) in radiation hardened technology is proposed and experimental results obtained comparing heavy-ion beam campaign demonstrated the feasibility of the proposed solution.
4 citations
01 Mar 2020
TL;DR: Evaluated software-based hardening techniques developed to detect SEUs in GPUs general-purpose registers are evaluated and proposed optimizations to improve performance and memory utilization are proposed.
Abstract: Graphics Processing Units (GPUs) are considered a promising solution for high-performance safety-critical applications, such as self-driving cars. In this application domain, the use of fault tolerance techniques is mandatory to detect or correct faults, since they must work properly even in the presence of faults. GPUs are designed with aggressive technology scaling, which makes them susceptible to faults caused by radiation interference, such as the Single Event Upsets (SEUs), which can lead the system to a failure, and that is unacceptable in safety-critical applications. In this paper, we evaluate different software-based hardening techniques developed to detect SEUs in GPUs general-purpose registers and propose optimizations to improve performance and memory utilization. The techniques are implemented in three case-study applications and evaluated in a general-purpose soft-core GPU based on the NVIDIA G80 architecture. A fault injection campaign is performed at register transfer level to assess the fault detection potential of the implemented techniques. Results show that the proposed improvements can be tailored for different scenarios, helping engineers in navigating the design space of hardened GPGPU applications.
4 citations
Cited by
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University of Helsinki1, Semmelweis University2, University of Szeged3, Hungarian Academy of Sciences4, University of Palermo5, University of Porto6, Institute of Molecular Pathology and Immunology of the University of Porto7, Autonomous University of Barcelona8, Instituto de Biologia Molecular e Celular9, Ikerbasque10, Harvard University11, University of Duisburg-Essen12, Salk Institute for Biological Studies13, Paracelsus Private Medical University of Salzburg14, University of Colorado Denver15, Bilkent University16, Middle East Technical University17, University of Southern Denmark18, Statens Serum Institut19, Ghent University Hospital20, Oslo University Hospital21, University of Belgrade22, University of Ljubljana23, University of Mainz24, Finnish Red Cross25, University of Gothenburg26, Latvian Biomedical Research and Study centre27, University of Applied Sciences and Arts Northwestern Switzerland FHNW28, University of Valencia29, Centro Nacional de Investigaciones Cardiovasculares30, University of Freiburg31, Utrecht University32, Trinity College, Dublin33, University of Barcelona34, Catalan Institution for Research and Advanced Studies35, International University Of Catalonia36, Aarhus University Hospital37
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Abstract: In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
3,690 citations
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
Abstract: Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.
2,507 citations
TL;DR: Emerging principles of miRNA regulation of stress signaling pathways are reviewed and applied to the authors' understanding of the roles of miRNAs in disease.
1,491 citations
TL;DR: The results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.
Abstract: The shear-responsive transcription factor Kruppel-like factor 2 (KLF2) is a critical regulator of endothelial gene expression patterns induced by atheroprotective flow. As microRNAs (miRNAs) post-transcriptionally control gene expression in many pathogenic and physiological processes, we investigated the regulation of miRNAs by KLF2 in endothelial cells. KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster. Interestingly, miR-143/145 has been shown to control smooth muscle cell (SMC) phenotypes; therefore, we investigated the possibility of transport of these miRNAs between endothelial cells and SMCs. Indeed, extracellular vesicles secreted by KLF2-transduced or shear-stress-stimulated HUVECs are enriched in miR-143/145 and control target gene expression in co-cultured SMCs. Extracellular vesicles derived from KLF2-expressing endothelial cells also reduced atherosclerotic lesion formation in the aorta of ApoE(-/-) mice. Combined, our results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.
1,182 citations
TL;DR: The information synthesized is expected to open new avenues for a large scale use of insect products as animal feed, and the levels of Ca and fatty acids in insect meals can be enhanced by manipulation of the substrate on which insects are reared.
1,068 citations