Author
Lucian V. Del Priore
Other affiliations: Johns Hopkins University, Medical University of South Carolina, Columbia University ...read more
Bio: Lucian V. Del Priore is an academic researcher from Yale University. The author has contributed to research in topics: Retinal pigment epithelium & Macular degeneration. The author has an hindex of 36, co-authored 113 publications receiving 5539 citations. Previous affiliations of Lucian V. Del Priore include Johns Hopkins University & Medical University of South Carolina.
Papers published on a yearly basis
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TL;DR: The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.
990 citations
University of Southern California1, Moorfields Eye Hospital2, Johns Hopkins University3, Manchester Royal Eye Hospital4, University of Pennsylvania5, University of California, San Francisco6, Massachusetts Eye and Ear Infirmary7, Wills Eye Institute8, Monterrey Institute of Technology and Higher Education9, Lighthouse International10, Columbia University11
TL;DR: The long-term safety results of Second Sight's retinal prosthesis system are acceptable, and most subjects with profound visual loss perform better on visual tasks with system than without it.
608 citations
TL;DR: Photocoagulation-induced drusen regression might prevent patients withdrusen from developing exudative maculopathy, and Sarks and coworkers proposed that this in turn will eliminate the potential cleavage plane between the RPE basement membrane and inner collagenous layer of Bruch's membrane through which CNVs grow, thus retarding the growth of CNVs.
312 citations
TL;DR: The results confirmed that hESC-derived cells could serve as a potentially safe new source for regenerative medicine and improve visual acuity in four Asian patients with dry age-related macular degeneration.
Abstract: Embryonic stem cells hold great promise for various diseases because of their unlimited capacity for self-renewal and ability to differentiate into any cell type in the body. However, despite over 3 decades of research, there have been no reports on the safety and potential efficacy of pluripotent stem cell progeny in Asian patients with any disease. Here, we report the safety and tolerability of subretinal transplantation of human embryonic-stem-cell (hESC)-derived retinal pigment epithelium in four Asian patients: two with dry age-related macular degeneration and two with Stargardt macular dystrophy. They were followed for 1 year. There was no evidence of adverse proliferation, tumorigenicity, ectopic tissue formation, or other serious safety issues related to the transplanted cells. Visual acuity improved 9–19 letters in three patients and remained stable (+1 letter) in one patient. The results confirmed that hESC-derived cells could serve as a potentially safe new source for regenerative medicine.
309 citations
University College London1, University of Southern California2, Johns Hopkins University3, Vision Institute4, Manchester Academic Health Science Centre5, University of Geneva6, Monterrey Institute of Technology and Higher Education7, University of Pennsylvania8, University of California, San Francisco9, Harvard University10, Northwestern University11, Wills Eye Institute12, Columbia University13
TL;DR: The 5-year results of theArgus II trial support the long-term safety profile and benefit of the Argus II System for patients blind as a result of RP.
271 citations
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TL;DR: An overview of the composition and structure of selected ECM scaffolding materials, the effects of manufacturing methods upon the structural properties and resulting mechanical behavior of the scaffold materials, and the in vivo degradation and remodeling of ECm scaffolds with an emphasis on tissue function is provided.
1,345 citations
TL;DR: The first description of hESC-derived cells transplanted into human patients with Stargardt's macular dystrophy and dry age-related macular degeneration is provided, with no signs of hyperproliferation, tumorigenicity, ectopic tissue formation, or apparent rejection after 4 months.
1,319 citations
TL;DR: An integrated ultrastructural, histochemical, molecular biological, and biochemical approach is described to identify specific molecular pathways associated with drusen biogenesis and invokes, for the first time, the potential for a direct role of cell- and immune-mediated processes in drusens biogenesis.
1,271 citations
TL;DR: Data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation.
Abstract: Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch's membrane and are risk factors for developing age-related macular degeneration (AMD). The progression of AMD might be slowed or halted if the formation of drusen could be modulated. To work toward a molecular understanding of drusen formation, we have developed a method for isolating microgram quantities of drusen and Bruch's membrane for proteome analysis. Liquid chromatography tandem MS analyses of drusen preparations from 18 normal donors and five AMD donors identified 129 proteins. Immunocytochemical studies have thus far localized ≈16% of these proteins in drusen. Tissue metalloproteinase inhibitor 3, clusterin, vitronectin, and serum albumin were the most common proteins observed in normal donor drusen whereas crystallin was detected more frequently in AMD donor drusen. Up to 65% of the proteins identified were found in drusen from both AMD and normal donors. However, oxidative protein modifications were also observed, including apparent crosslinked species of tissue metalloproteinase inhibitor 3 and vitronectin, and carboxyethyl pyrrole protein adducts. Carboxyethyl pyrrole adducts are uniquely generated from the oxidation of docosahexaenoate-containing lipids. By Western analysis they were found to be more abundant in AMD than in normal Bruch's membrane and were found associated with drusen proteins. Carboxymethyl lysine, another oxidative modification, was also detected in drusen. These data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation.
1,159 citations
TL;DR: Clinical investigations using stem cell products in regenerative medicine are addressing a wide spectrum of conditions using a variety of stem cell types and applications are progressing in trials, some with early benefits to patients.
1,040 citations