L
Luciana Madeira da Silva
Researcher at University of South Alabama
Publications - 23
Citations - 697
Luciana Madeira da Silva is an academic researcher from University of South Alabama. The author has contributed to research in topics: Cancer & Ovarian cancer. The author has an hindex of 10, co-authored 20 publications receiving 534 citations. Previous affiliations of Luciana Madeira da Silva include Washington University in St. Louis & University of Miami.
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Journal ArticleDOI
ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.
Erhong Meng,Aparna Mitra,Kaushlendra Tripathi,Michael A. Finan,Jennifer Scalici,Steve McClellan,Luciana Madeira da Silva,Eddie Reed,Lalita A. Shevde,Komaraiah Palle,Rodney P. Rocconi +10 more
TL;DR: It is suggested that ovarian cancer cells expressing ALDH1A1 may maintain platinum resistance by altered regulation of cell cycle checkpoint and DNA repair network signaling.
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Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Sangbin Lim,Hao Liu,Hao Liu,Luciana Madeira da Silva,Ritu Arora,Zixing Liu,Joshua B. Phillips,David C. Schmitt,Tung Vu,Steven McClellan,Yifeng Lin,Wensheng Lin,Gary A. Piazza,Øystein Fodstad,Ming Tan +14 more
TL;DR: The results illuminate the critical immune-independent contributions of B7-H3 to cancer metabolism, presenting a radically new perspective on B7 family immunoregulatory proteins in malignant progression.
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Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity
TL;DR: The TOR kinase family has expanded to encompass a unique role in AC function and biology, one that is essential for parasite survival in the mammalian infective stage of trypanosomatids and offers an attractive target for chemotherapy.
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The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing
Rosario Diaz-Gonzalez,F. Matthew Kuhlmann,Cristina Galan-Rodriguez,Luciana Madeira da Silva,Manuel Saldivia,Caitlin E. Karver,Ana Rodriguez,Stephen M. Beverley,Miguel Navarro,Michael P. Pollastri +9 more
TL;DR: These studies strongly suggest that mammalian PI3/TOR kinase inhibitors are a productive starting point for anti-trypanosomal drug discovery and suggest that NVP-BEZ235, an advanced clinical candidate against solid tumors, merits further investigation as an agent for treating African sleeping sickness.
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Interplay between Immune Checkpoint Proteins and Cellular Metabolism.
Sangbin Lim,Joshua B. Phillips,Luciana Madeira da Silva,Ming Zhou,Øystein Fodstad,Laurie B. Owen,Ming Tan +6 more
TL;DR: How cancer cells with altered expression of immune checkpoint proteins can potently inhibit immune function through the alteration of cellular and microenvironmental metabolism is discussed, providing a new perspective on the interplay between these pathways and offering a potential therapeutic intervention strategy in the treatment of malignant disease.