Luciana Sampieri

TL;DR: An overview of the diverse functions of each member of the CREB3 family of transcription factors with special focus on their role in the central nervous system is provided.

TL;DR: The results show a Rab1b increase in secretory cells after stimulation and suggest that this increase is required to elicit a secretory response.

TL;DR: CREB3L1 has a role during the adaptation of the secretory pathway in response to high secretory demand in thyroid cells, a process with direct impact on thyroid physiology.

TL;DR: Rab1b localization time at ERES depended on GBF1, a Rab1b effector that acts as the guanine nucleotide exchange factor of Arf1, and that Rab 1b membrane association/dissociation dynamics at ER ES was dependent on the GBF 1 membrane association and activity, which strongly suggests that GBF2 activity modulates Rab1B membrane cycling dynamic.

TL;DR: In this paper, the expression and signaling mechanism of CREB3 transcription factor family members were analyzed using the NGF-induced PC12 cell differentiation model, showing that NGF treatment causes Golgi enlargement and a parallel increased expression of proteins and mRNAs encoding for proteins required for membrane transport (transport factors).