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Lucy D Brennan
Researcher at University of California, San Francisco
Publications - 3
Citations - 119
Lucy D Brennan is an academic researcher from University of California, San Francisco. The author has an hindex of 2, co-authored 3 publications receiving 20 citations. Previous affiliations of Lucy D Brennan include University of California, Berkeley.
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Journal ArticleDOI
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +11 more
TL;DR: In this article, the phase-separation by HP1 proteins can explain the biological properties of HP1-mediated heterochromatin, and the authors suggest a generalizable model for genome organization in which a pool of weakly bound proteins collectively capitalize on the polymer properties of DNA to produce self-organizing domains.
Peer ReviewDOI
Author response: HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +12 more
Posted ContentDOI
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +12 more
TL;DR: A generalizable model for genome organization is suggested in which a pool of weakly bound proteins collectively capitalize on the polymer properties of DNA to produce self-organizing domains that are simultaneously resistant to large forces at the mesoscale and susceptible to competition at the molecular scale.