L
Ludovic Renault
Researcher at Leiden University
Publications - 35
Citations - 1786
Ludovic Renault is an academic researcher from Leiden University. The author has contributed to research in topics: Helicase & Protein structure. The author has an hindex of 19, co-authored 34 publications receiving 1427 citations. Previous affiliations of Ludovic Renault include Aix-Marseille University & Francis Crick Institute.
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Journal ArticleDOI
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
Aline C. Simon,Jin C. Zhou,Rajika L. Perera,Rajika L. Perera,Frederick van Deursen,Cecile Evrin,Marina E. Ivanova,Marina E. Ivanova,Mairi L. Kilkenny,Ludovic Renault,Svend Kjaer,Dijana Matak-Vinkovic,Karim Labib,Alessandro Costa,Luca Pellegrini +14 more
TL;DR: The findings indicate that Ctf4 can couple two molecules of Pol α to one CMG helicase within the replisome, providing a new model for lagging-strand synthesis in eukaryotes that resembles the emerging model for the simpler replisomes of Escherichia coli.
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Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation.
Jie Liu,Ludovic Renault,Xavier Veaute,Francis Fabre,Henning Stahlberg,Henning Stahlberg,Wolf Dietrich Heyer +6 more
TL;DR: It is proposed that the Rad51 presynaptic filament is a meta-stable reversible intermediate, whose assembly and disassembly is governed by the balance between Rad55–Rad57 and Srs2, providing a key regulatory mechanism controlling the initiation of homologous recombination.
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ESTHER, the database of the α/β‐hydrolase fold superfamily of proteins
Thierry Hotelier,Ludovic Renault,Xavier Cousin,Vincent Negre,Pascale Marchot,Arnaud Chatonnet +5 more
TL;DR: The ESTHER database gathers and annotates all the published information related to gene and protein sequences of this superfamily, as well as biochemical, pharmacological and structural data, and connects them so as to provide the bases for studying structure–function relationships within the family.
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Structural basis for retroviral integration into nucleosomes
Daniel P. Maskell,Ludovic Renault,Erik Serrao,Paul Lesbats,Rishi Matadeen,Stephen Hare,Dirk Lindemann,Alan Engelman,Alessandro Costa,Peter Cherepanov +9 more
TL;DR: It is shown that the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets for integration, and the molecular basis for nucleosome capture by the viral DNA recombination machinery and the underlying nucleosomal plasticity that allows integration is elucidated.
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The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
Ester Vázquez-Fernández,Matthijn R. J. Vos,Pavel Afanasyev,Lino Cebey,Alejandro M. Sevillano,Enric Vidal,Isaac Rosa,Ludovic Renault,Adriana Ramos,Peter J. Peters,José-Jesús Fernández,Marin van Heel,Howard S. Young,Jesús R. Requena,Holger Wille +14 more
TL;DR: The repetitive organization inherent to GPI-anchorless PrP 27–30 amyloid fibrils is used to analyze their structure via electron cryomicroscopy and indicate a four-rung β-solenoid structure as a key feature for the architecture of infectious mammalian prions.