L
Luigi Biancone
Researcher at University of Turin
Publications - 188
Citations - 8717
Luigi Biancone is an academic researcher from University of Turin. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 36, co-authored 170 publications receiving 7734 citations. Previous affiliations of Luigi Biancone include CTO Hospital & University of Parma.
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Exosomes/microvesicles as a mechanism of cell-to-cell communication
TL;DR: The transfer of gene products from injured cells may explain stem cell functional and phenotypic changes without the need of transdifferentiation into tissue cells, and the evidence supporting a bidirectional exchange of genetic information between stem and injured cells is discussed.
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Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.
Maria Chiara Deregibus,Vincenzo Cantaluppi,Raffaele A. Calogero,Marco Lo Iacono,Ciro Tetta,Luigi Biancone,Stefania Bruno,Benedetta Bussolati,Giovanni Camussi +8 more
TL;DR: Protein expression and functional studies showed that PI3K and eNOS play a critical role in the angiogenic effect of MVs, suggesting that EPCs may activate angiogenesis in endothelial cells by releasing MVs able to trigger an angiogens program.
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Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury
Stefania Bruno,Cristina Grange,Federica Collino,Maria Chiara Deregibus,Vincenzo Cantaluppi,Luigi Biancone,Ciro Tetta,Giovanni Camussi +7 more
TL;DR: MVs released from MSCs were found to exert a pro-survival effect on renal cells in vitro and in vivo, suggesting that MVs may contribute to renal protection conferred by M SCs.
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Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells
Vincenzo Cantaluppi,Stefano Gatti,Davide Medica,Federico Figliolini,Stefania Bruno,Maria Chiara Deregibus,Andrea Sordi,Luigi Biancone,Ciro Tetta,Giovanni Camussi +9 more
TL;DR: Microvesicles derived from endothelial progenitor cells protect the kidney from ischemic acute injury by delivering their RNA content, the miRNA cargo of which contributes to reprogramming hypoxic resident renal cells to a regenerative program.
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Therapeutic potential of mesenchymal stem cell-derived microvesicles
TL;DR: Whether MVs released from mesenchymal stem cells have the potential to be exploited in novel therapeutic approaches in regenerative medicine to repair damaged tissues, as an alternative to stem cell-based therapy is discussed.