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Luigi Puglielli

Researcher at University of Wisconsin-Madison

Publications -  75
Citations -  10660

Luigi Puglielli is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Endoplasmic reticulum & Acetylation. The author has an hindex of 32, co-authored 68 publications receiving 8875 citations. Previous affiliations of Luigi Puglielli include Pontifical Catholic University of Chile & Veterans Health Administration.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Alzheimer's disease: the cholesterol connection

Luigi Puglielli, +2 more
- 01 Apr 2003 - 
TL;DR: The identification of a variant of the apolipoprotein E (APOE) gene as a major genetic risk factor for AD is also consistent with a role for cholesterol in the pathogenesis of AD.
Journal ArticleDOI

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

Luigi Puglielli, +8 more
- 01 Oct 2001 - 
TL;DR: It is found that cholesteryl-ester levels are directly correlated with Aβ production, and pharmacological inhibitors of ACAT, developed for the treatment of atherosclerosis, are potent modulators of Aβ generation, indicating their potential for use in thereatment of Alzheimer's disease.
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Ceramide Stabilizes β-Site Amyloid Precursor Protein-cleaving Enzyme 1 and Promotes Amyloid β-Peptide Biogenesis

Luigi Puglielli, +3 more
- 30 May 2003 - 
TL;DR: Data indicate that the lipid second messenger ceramide, which is elevated in the brains of Alzheimer's disease patients, increases the half-life of BACE1 and thereby promotes Aβ biogenesis.