Luis-Carlos Tábara

TL;DR: VMP1, a multispanning ER-resident protein involved in autophagy, is enriched in ER micro-domains that are in close proximity to diverse organelles in HeLa and Cos-7 cells, suggesting a role in the regulation of MCS at the site of autophagosome formation.

TL;DR: Changes in the activity of endogenous TKT activity in strains lacking or overexpressing Atg1 are found, suggesting the presence of an unsuspected regulatory pathway between autophagy and the pentose phosphate pathway in Dictyostelium that seems to be conserved in mammalian cells.

TL;DR: The role of VMP1 in lipid trafficking is expanded to include endoplasmic reticulum domains enriched in lipid synthesizing enzymes, which might be necessary for efficient distribution of PtdIns4P and perhaps other lipid species.

TL;DR: This work shows that VMP1 from different species contain two short motifs conserved in the bacterial DedA proteins and the yeast protein Tvp38, and highlights the importance of the conserved glycine residue in the PF09335 domain.

TL;DR: In this article, the authors have generated mutants for the two PROPPIN proteins present in the model system Dictyostelium discoideum (Atg18 and Wdr45l) and characterized their function.