L
Luis J. Flores
Researcher at University of Texas Health Science Center at San Antonio
Publications - 9
Citations - 2871
Luis J. Flores is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 9, co-authored 9 publications receiving 2632 citations. Previous affiliations of Luis J. Flores include University of Texas at San Antonio.
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Journal ArticleDOI
One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
TL;DR: This review focuses on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential regulatory mechanisms, bioavailability in humans, mechanisms of breakdown and functions of its metabolites.
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Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions.
TL;DR: The review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals.
Journal Article
Medical implications of melatonin: receptor-mediated and receptor-independent actions.
Russel J. Reiter,Dun Xian Tan,Lucien C. Manchester,M. Pilar Terron,Luis J. Flores,S. Koppisepi +5 more
TL;DR: Among the actions of melatonin that are likely receptor independent and that are reviewed herein include its ability to neutralize free radicals which leads to a reduction in cataract formation, reducing oxidative stress due to exposure to hyperbaric hyperoxia, ameliorating hyperthyroidism and abating the toxicity of sepsis and septic shock.
Journal ArticleDOI
Melatonin and pregnancy in the human.
Hiroshi Tamura,Yasuhiko Nakamura,M. Pilar Terron,Luis J. Flores,Lucien C. Manchester,Lucien C. Manchester,Dun Xian Tan,Norihiro Sugino,Russel J. Reiter +8 more
TL;DR: Melatonin is a neuroendocrine hormone secreted nightly by pineal gland and regulates biological rhythms and it appears to be essential for successful pregnancy.
Journal ArticleDOI
The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma.
M.D. Maldonado,Francisco Murillo-Cabezas,M. P. Terron,Luis J. Flores,Dan Xian Tan,Lucien C. Manchester,Russel J. Reiter +6 more
TL;DR: Melatonin crosses the blood–brain barrier and reduces contusion volume and stabilizes cellular membranes preventing vasospasm and apoptosis of endothelial cells that occurs as a result of CCT.