Luisa Craviotto

TL;DR: Osteocyte autophagy is identified as a new potential target in MM bone disease and the use of PIs to maintain osteocyte viability and improve bone integrity in MM patients is supported.

TL;DR: The relationship between bone disease and the BM cytokine and chemokine patterns highlighting the tight relationship between CCL20 BM levels and osteolysis in multiple myeloma patients is defined.

TL;DR: The absence of any detrimental effect on marrow engraftment in vivo supports the safety of the CFU-Blast assay to evaluate the dose of mafosfamide used for marrow purging before ABMT.

TL;DR: It is demonstrated that PMF megakaryocytic cultures express higher levels of PKCɛ than healthy donors, which correlate with higher disease burden but not with JAK2V617F mutation, and represents a proof-of-concept for PKC∛ inhibition as a novel therapeutic strategy in PMF.

TL;DR: It is found that the ratio between monocytes (CD14+) and MM cells (CD138+) influences the response to DARA, which underlines the critical role of the CD16+ monocytes in DARA anti‐MM killing effects and gives a rationale to test the combination of an anti‐CD47 mAb with anti-CD38 mAbs.