L
Luiz C. Dias
Researcher at State University of Campinas
Publications - 157
Citations - 2420
Luiz C. Dias is an academic researcher from State University of Campinas. The author has contributed to research in topics: Aldol reaction & Total synthesis. The author has an hindex of 24, co-authored 153 publications receiving 2255 citations. Previous affiliations of Luiz C. Dias include Harvard University.
Papers
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Journal ArticleDOI
Enantioselective total synthesis of altohyrtin c (spongistatin 2)
David A. Evans,B. Wesley Trotter,Paul J. Coleman,Cote Bernard,Luiz C. Dias,Hemaka A. Rajapakse,Andrew N. Tyler +6 more
TL;DR: The first total synthesis of a spongipyran macrolide, altohyrtin C, was described in this paper, which relies on a regioselective macrolactonization, a stere-lective Wittig coupling of the two major synthetic fragments, a complex anti-aldol reaction to join the C1-C15 and C16-C28 spiroketal regions, and an anomeric sulfone acylation to join C29-C37 and C38-C43 pyran regions.
Journal ArticleDOI
Enantioselective synthesis of altohyrtin c (spongistatin 2) : fragment assembly and revision of the spongistatin 2 stereochemical assignment
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Chiral Lewis acid catalysts in diels-Alder cycloadditions: mechanistic aspects and synthetic applications of recent systems
TL;DR: A review of the use of chiral Lewis acid catalysts in Diels-Alder cycloaddition reactions can be found in this paper, where structural studies on Lewis acid carbonyl complexes and synthetic applications of recent systems are discussed.
Journal ArticleDOI
Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Synthesis of the AB- and CD-Spiroketal Subunits†‡
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Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos
Luiz C. Dias,Marco A. Dessoy,Jean Jerley Nogueira da Silva,Otavio Henrique Thiemann,Glaucius Oliva,Adriano D. Andricopulo +5 more
TL;DR: A brief review attempts to highlight the state of the art, limitations and perspectives of Chagas' disease drug development.