L
Luiza Moore
Researcher at Wellcome Trust Sanger Institute
Publications - 46
Citations - 3284
Luiza Moore is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Somatic cell & Germline mutation. The author has an hindex of 16, co-authored 39 publications receiving 1285 citations. Previous affiliations of Luiza Moore include Cambridge University Hospitals NHS Foundation Trust & National Institute for Health Research.
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Journal ArticleDOI
The landscape of somatic mutation in normal colorectal epithelial cells
Henry Lee-Six,Sigurgeir Olafsson,Peter D. Ellis,Robert J. Osborne,Mathijs A. Sanders,Mathijs A. Sanders,Luiza Moore,Nikitas Georgakopoulos,Franco Torrente,Ayesha Noorani,Ayesha Noorani,Martin Goddard,Philip Robinson,Tim H. H. Coorens,Laura O’Neill,Christopher Alder,Jingwei Wang,Rebecca C. Fitzgerald,Rebecca C. Fitzgerald,Matthias Zilbauer,Nicholas Coleman,Nicholas Coleman,Kourosh Saeb-Parsy,Inigo Martincorena,Peter J. Campbell,Michael R. Stratton +25 more
TL;DR: Genome sequencing of hundreds of normal colonic crypts from 42 individuals sheds light on mutational processes and driver mutations in normal colorectal epithelial cells, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorean epithelium.
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Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis
Yu Fu,Alexander W. Jung,Ramón Viñas Torné,Ramón Viñas Torné,Santiago Gonzalez,Harald Vöhringer,Artem Shmatko,Artem Shmatko,Lucy R. Yates,Mercedes Jimenez-Linan,Luiza Moore,Moritz Gerstung +11 more
TL;DR: Deep transfer learning is used to quantify histopathological patterns across 17,355 hematoxylin and eosin-stained histopathology slide images from 28 cancer types and correlate these with matched genomic, transcriptomic and survival data, showing the remarkable potential of computer vision in characterizing the molecular basis of tumor Histopathology.
Journal ArticleDOI
The mutational landscape of normal human endometrial epithelium
Luiza Moore,Luiza Moore,Daniel Leongamornlert,Tim H. H. Coorens,Mathijs A. Sanders,Mathijs A. Sanders,Peter D. Ellis,Stefan C. Dentro,Stefan C. Dentro,Kevin J. Dawson,Tim Butler,Raheleh Rahbari,Thomas J. Mitchell,Francesco Maura,Francesco Maura,Jyoti Nangalia,Patrick S. Tarpey,Simon F. Brunner,Henry Lee-Six,Yvette Hooks,Sarah Moody,Krishnaa T. Mahbubani,Mercedes Jimenez-Linan,Jan J. Brosens,Christine A. Iacobuzio-Donahue,Inigo Martincorena,Kourosh Saeb-Parsy,Peter J. Campbell,Michael R. Stratton +28 more
TL;DR: The results show that mutational landscapes differ markedly between normal tissues—perhaps shaped by differences in their structure and physiology—and indicate that the procession of neoplastic change that leads to endometrial cancer is initiated early in life.
Journal ArticleDOI
Copy number signatures and mutational processes in ovarian carcinoma
Geoff Macintyre,Teodora Goranova,D.G.H. de Silva,Darren Ennis,Anna M. Piskorz,Matthew D. Eldridge,Daoud Sie,Liz Anne Lewsley,Aishah Hanif,Cheryl Wilson,Suzanne Dowson,Rosalind Glasspool,Michelle Lockley,Michelle Lockley,Elly Brockbank,Ana Montes,Axel Walther,Sudha Sundar,Richard J. Edmondson,Richard J. Edmondson,Geoff Hall,Andrew R Clamp,Charlie Gourley,Marcia Hall,Christina Fotopoulou,Hani Gabra,Hani Gabra,James Paul,Anna Supernat,David Millan,Aoisha Hoyle,Gareth Bryson,Craig Nourse,Laura Mincarelli,Luis Navarro Sanchez,Bauke Ylstra,Mercedes Jimenez-Linan,Luiza Moore,Oliver Hofmann,Oliver Hofmann,Florian Markowetz,Iain A. McNeish,Iain A. McNeish,Iain A. McNeish,James D. Brenton +44 more
TL;DR: It is shown that HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in known patterns of genomic aberration, and copy number signature exposures at diagnosis predict both overall survival and the probability of platinum-resistant relapse.
Journal ArticleDOI
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.
Simon F. Brunner,Nicola D. Roberts,Luke A. Wylie,Luiza Moore,Sarah J. Aitken,Susan E. Davies,Mathijs A. Sanders,Mathijs A. Sanders,Peter R. Ellis,Chris Alder,Yvette Hooks,Federico Abascal,Michael R. Stratton,Inigo Martincorena,Matthew Hoare,Peter J. Campbell,Peter J. Campbell +16 more
TL;DR: It is shown that cirrhotic liver has a higher mutational burden than normal liver, and structural variants, including chromothripsis, were prominent in cirrhosis.