/pdf/high-resolution-x-ray-computed-tomography-in-geosciences-a-3sj7249knj.pdf

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

The ability of dual- and multi-energy CT to differentiate materials of different effective atomic numbers makes possible several new and clinically relevant CT applications.

Dual- and Multi-Energy CT: Principles, Technical Approaches, and Clinical Applications

http://research.engr.oregonstate.edu/immiscibles/sites/research.engr.oregonstate.edu.immiscibles/files/Papers/Wildenschild_Sheppard_AWR_2012.pdf

X-ray imaging and analysis techniques for quantifying pore-scale structure and processes in subsurface porous medium systems

Photon counting detectors (PCDs) with energy discrimination capabilities have been developed for medical x-ray computed tomography (CT) and x-ray (XR) imaging. Using detection mechanisms that are completely different from the current energy integrating detectors and measuring the material information of the object to be imaged, these PCDs have the potential not only to improve the current CT and XR images, such as dose reduction, but also to open revolutionary novel applications such as molecular CT and XR imaging. The performance of PCDs is not flawless, however, and it seems extremely challenging to develop PCDs with close to ideal characteristics. In this paper, the authors offer our vision for the future of PCD-CT and PCD-XR with the review of the current status and the prediction of (1) detector technologies, (2) imaging technologies, (3) system technologies, and (4) potential clinical benefits with PCDs.

/pdf/vision-20-20-single-photon-counting-x-ray-detectors-in-2ozmq4m8yc.pdf

Vision 20/20: Single photon counting x-ray detectors in medical imaging

The PILATUS 1M detector is a hybrid pixel array detector with over one million pixels that operate in single photon counting mode. The detector, designed for macromolecular crystallography, is the largest pixel array detector currently in use at a synchrotron. It is a modular system consisting of 18 multichip modules covering an area of 21 cm × 24 cm. The design of the components as well as the manufacturing of the detector including the bump-bonding was performed at the Paul Scherrer Institute (PSI). The use of a single photon counting detector for protein crystallography requires detailed studies of the charge collection properties of the silicon sensor. The 18 modules are read out in parallel, leading to a full frame readout-time of 6.7 ms. This allows crystallographic data to be acquired in fine-φ-slicing mode with continuous rotation of the sample. The detector was tested in several experiments at the protein crystallography beamline X06SA at the Swiss Light Source at PSI. Data were collected both in conventional oscillation mode using the shutter, as well as in a fine-φ-slicing mode. After applying all the necessary corrections to data from a thaumatin crystal, the processing of the conventional data led to satisfactory merging R-factors of the order of 8.5%. This allows, for the first time, determination of a refined electron density map of a macromolecular biological crystal using a silicon pixel detector.

https://www.dora.lib4ri.ch/psi/islandora/object/psi%3A16541/datastream/PDF/Broennimann-2006-The_PILATUS_1M_detector-%28published_version%29.pdf

The PILATUS 1M detector.

A novel approach for the readout of a TPC at the future linear collider is to use a CMOS pixel detector combined with some kind of gas gain grid. A first test using the photon counting chip Medipix2 with GEM or Micromegas demonstrated the feasibility of such an approach. Although this experiment demonstrated that single primary electrons could be detected the chip did not provide information on the arrival time of the electron in the sensitive gas volume nor did it give any indication of the quantity of charge detected. The Timepix chip uses an external clock with a frequency of up to 100 MHz as a time reference. Each pixel contains a preamplifier, a discriminator with hysteresis and 4-bit DAC for threshold adjustment, synchronization logic and a 14-bit counter with overflow control. Moreover, each pixel can be independently configured in one of four different modes: masked mode: pixel is off, counting mode: 1-count for each signal over threshold, TOT mode: the counter is incremented continuously as long as the signal is above threshold, and arrival time mode: the counter is incremented continuously from the time the first hit arrives until the end of the shutter. The chip resembles very much the Medipix2 chip physically and can be readout using slightly modified versions of the various existing systems. This paper presents the main features of the new design, electrical measurements and some first images.

Timepix, a 65k programmable pixel readout chip for arrival time, energy and/or photon counting measurements

A prototype pixel detector readout chip has been developed with a new front-end architecture aimed at eliminating the spectral distortion produced by charge diffusion in highly segmented semiconductor detectors. In the new architecture neighbouring pixels communicate with one another. At the corner of each pixel summing circuits add the total charge deposited in each sub-group of 4 pixels. Arbitration logic assigns a hit to the summing circuit with the highest charge. In the case where incoming X-ray photons produce fluorescence-a particular issue in high-Z materials-the charge deposited by those fluorescent photons will be included in the charge sum provided that the deposition takes place within the volume of the pixels neighbouring the initial impact point. The chip is configurable such that either the dimensions of each detector pixel match those of one readout pixel or detector pixels are 4 times greater in area than the readout pixels. In the latter case event-by-event summing is still possible between the larger pixels. As well as this innovative analog front-end circuit, each pixel contains comparators, logic circuits and two 15-bit counters. When the larger detector pixels are used these counters can be configured to permit multiple thresholds in a pixel providing spectroscopic information. The prototype chip has been designed and manufactured in an 8-metal 0.13 mum CMOS technology. First measurements show an electronic pixel noise of ~ 72 e-rms (Single Pixel Mode) and ~ 140 e-rms (Charge Summing Mode).

/pdf/the-medipix3-prototype-a-pixel-readout-chip-working-in-1exr3zqww3.pdf

The Medipix3 Prototype, a Pixel Readout Chip Working in Single Photon Counting Mode with Improved Spectrometric Performance

The Medipix3 chips have been designed to permit spectroscopic imaging in highly segmented hybrid pixel detectors. Spectral degradation due to charge sharing in the sensor has been addressed by means of an architecture in which adjacent pixels communicate in the analog and digital domains on an event-by-event basis to reconstruct the deposited charge in a neighbourhood prior to the assignation of the hit to a single pixel. The Medipix3RX chip architecture is presented. The first results for the characterization of the chip with 300 μm thick Si sensors are given. ~ 72e− r.m.s. noise and ~ 40e− r.m.s. of threshold dispersion after chip equalization have been measured in Single Pixel Mode of operation. The homogeneity of the image in Charge Summing mode is comparable to the Single Pixel Mode image. This demonstrates both modes are suitable for X-ray imaging applications.

/pdf/the-medipix3rx-a-high-resolution-zero-dead-time-pixel-tpmlv2e7nw.pdf

The Medipix3RX: a high resolution, zero dead-time pixel detector readout chip allowing spectroscopic imaging

Hybrid pixel detectors have been demonstrated to provide excellent quality detection of ionising photon radiation, particularly in X-ray imaging. Recently, there has been interest in developing a hybrid pixel detector specifically for photon dosimetry. This thesis is on the design, implementation, and preliminary characterisation of the Dosepix readout chip.Dosepix has 256 square pixels of 220 mm side-length, constituting 12.4 mm2 of photo-sensitive area per detector. The combination of multiple pixels provides many parallel processors with limited input flux, resulting in a radiation dose monitor which can continuously record data and provide a real-time report on personal dose equivalent. Energy measurements are obtained by measuring the time over threshold of each photon and a state machine in the pixel sorts the detected photon event into appropriate energy bins. Each pixel contains 16 digital thresholds with 16 registers to store the associated energy bins. Preliminary measurements of Dosepix chips bump bonded to silicon sensors show very promising results. The pixel has a frontend noise of 120 e-. In low power mode, each chip consumes 15 mW, permitting its use in a portable, battery-powered system. Direct time over threshold output from the hybrid pixel detector assembly reveal distinctive photo-peaks correctly identifying the nature of incident photons, and verification measurements indicate that the pixel binning state machines accurately categorise charge spectra. Personal dose equivalent reconstruction using this data has a flat response for a large range of photon energies and personal dose equivalent rates.

Medipix3: A 64 k pixel detector readout chip working in single photon counting mode with improved spectrometric performance

Semiconductor detector readout chips with pulse processing electronics have made possible spectroscopic X-ray imaging, bringing an improvement in the overall image quality and, in the case of medical imaging, a reduction in the X-ray dose delivered to the patient. In this contribution we review the state of the art in semiconductor-detector readout ASICs for spectroscopic X-ray imaging with emphasis on hybrid pixel detector technology. We discuss how some of the key challenges of the technology (such as dealing with high fluxes, maintaining spectral fidelity, power consumption density) are addressed by the various ASICs. In order to understand the fundamental limits of the technology, the physics of the interaction of radiation with the semiconductor detector and the process of signal induction in the input electrodes of the readout circuit are described. Simulations of the process of signal induction are presented that reveal the importance of making use of the small pixel effect to minimize the impact of the slow motion of holes and hole trapping in the induced signal in high-Z sensor materials. This can contribute to preserve fidelity in the measured spectrum with relatively short values of the shaper peaking time. Simulations also show, on the other hand, the distortion in the energy spectrum due to charge sharing and fluorescence photons when the pixel pitch is decreased. However, using recent measurements from the Medipix3 ASIC, we demonstrate that the spectroscopic information contained in the incoming photon beam can be recovered by the implementation in hardware of an algorithm whereby the signal from a single photon is reconstructed and allocated to the pixel with the largest deposition.

/pdf/review-of-hybrid-pixel-detector-readout-asics-for-r01xi789oa.pdf

Lukas Tlustos

Papers

Timepix, a 65k programmable pixel readout chip for arrival time, energy and/or photon counting measurements

The Medipix3 Prototype, a Pixel Readout Chip Working in Single Photon Counting Mode with Improved Spectrometric Performance

The Medipix3RX: a high resolution, zero dead-time pixel detector readout chip allowing spectroscopic imaging

Medipix3: A 64 k pixel detector readout chip working in single photon counting mode with improved spectrometric performance

Review of hybrid pixel detector readout ASICs for spectroscopic X-ray imaging