Author
Lukasz Koroniak
Other affiliations: University of California, Los Angeles
Bio: Lukasz Koroniak is an academic researcher from University of Florida. The author has contributed to research in topics: Allylic rearrangement & Asparagine synthetase. The author has an hindex of 6, co-authored 10 publications receiving 238 citations. Previous affiliations of Lukasz Koroniak include University of California, Los Angeles.
Papers
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TL;DR: In this article, several synthetic pathways to cyclohex-5-ene-1R,2S,3R,4R-tetrol (conduritol C) and cycloencoderhex-1S,2R, 3R, 4R, 6R, 7R, 8R, 9R, 12R, 14R, 15R, 16R, 17R, 18R, 19R, 20R, 21R, 22R, 23R, 24R, 25R, 26R, 27R, 28R,
91 citations
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TL;DR: In vitro experiments show an adenylated sulfoximine to be a slow-onset, tight-binding inhibitor of hASNS with nanomolar affinity, which represents a 10-fold improvement over that reported for the only other well-characterized hAS NS inhibitor.
52 citations
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TL;DR: This compound appears to be the first and only potent inhibitor of human asparagine synthetase that has been described to date and provides the basis for the discovery of new compounds with application in the treatment of drug-resistant leukemia.
47 citations
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TL;DR: An improved synthesis of the naturally occurring hydroxy ketone 1-palmitoyl-2-(5,6)-epoxyisoprostane E 2- sn-glycero-3-phosphocholine (PEIPC) 1, a compound that plays a role in endothelial activation in atherosclerosis, has been carried out using a PMB ether as the key protecting group.
32 citations
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TL;DR: Electrochemical methods provide for selective reduction of vinyl iodides over vinyl bromides, with better yields than analogous tin methodology.
Abstract: Several vinyl halides previously used in inositol syntheses were subjected to electrochemical reduction. The unreactivity of allylic alcohols or allylic ethers at the applied potentials allowed the...
23 citations
Cited by
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TL;DR: This review discusses advances in synthetic organic electrochemistry since 2000 with enabling methods and synthetic applications analyzed alongside innate advantages as well as future challenges of electroorganic chemistry.
Abstract: Electrochemistry represents one of the most intimate ways of interacting with molecules. This review discusses advances in synthetic organic electrochemistry since 2000. Enabling methods and synthetic applications are analyzed alongside innate advantages as well as future challenges of electroorganic chemistry.
1,930 citations
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TL;DR: In this article, the effect of the E Factor concept has had over the last fifteen years on developments in the chemical industry and pharmaceutical industry with regard to waste minimisation and to assess its current status in the broader context of green chemistry and sustainability.
1,206 citations
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TL;DR: The fundamental concepts underlying the principles of green and sustainable chemistry--atom and step economy and the E factor--are presented, within the general context of efficiency in organic synthesis, and the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.
Abstract: In this tutorial review, the fundamental concepts underlying the principles of green and sustainable chemistry - atom and step economy and the E factor - are presented, within the general context of efficiency in organic synthesis. The importance of waste minimisation through the widespread application of catalysis in all its forms – homogeneous, heterogeneous, organocatalysis and biocatalysis – is discussed. These general principles are illustrated with simple practical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones. The latter reaction is exemplified by a three enzyme process for the production of a key intermediate in the synthesis of the cholesterol lowering agent, atorvastatin. The immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) as a means of optimizing operational performance is presented. The use of immobilised enzymes in catalytic cascade processes is illustrated with a trienzymatic process for the conversion of benzaldehyde to (S)-mandelic acid using a combi-CLEA containing three enzymes. Finally, the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.
1,095 citations
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767 citations
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TL;DR: The optimisation of enzyme properties using in vitro evolution and improvement of their operational stability by immobilisation as cross-linked enzyme aggregates (CLEA) are presented and the biocatalytic aerobic oxidation of starch to carboxy starch is presented as an example of green chemistry in optima forma i.e. a biocompatible product from a renewable raw material using a biocesealytic air oxidation.
737 citations