Luke L. A. Price

Bio: Luke L. A. Price is an academic researcher from Public Health England. The author has contributed to research in topics: Circadian rhythm & Spectroradiometer. The author has an hindex of 9, co-authored 17 publications receiving 981 citations. Previous affiliations of Luke L. A. Price include Health Protection Agency.

Low-energy light bulbs, computers, tablets and the blue light hazard.

Abstract: The introduction of low energy lighting and the widespread use of computer and mobile technologies have changed the exposure of human eyes to light. Occasional claims that the light sources with emissions containing blue light may cause eye damage raise concerns in the media. The aim of the study was to determine if it was appropriate to issue advice on the public health concerns. A number of sources were assessed and the exposure conditions were compared with international exposure limits, and the exposure likely to be received from staring at a blue sky. None of the sources assessed approached the exposure limits, even for extended viewing times.

Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults

Abstract: Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms and sleep, as well as neuroendocrine and cognitive functions. Prevailing patterns of light exposure do not optimally engage these actions for many individuals, but advances in our understanding of the underpinning mechanisms and emerging lighting technologies now present opportunities to adjust lighting to promote optimal physical and mental health and performance. A newly developed, international standard provides a SI-compliant way of quantifying the influence of light on the intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate these effects. The present report provides recommendations for lighting, based on an expert scientific consensus and expressed in an easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. The recommendations are supported by detailed analysis of the sensitivity of human circadian, neuroendocrine, and alerting responses to ocular light and provide a straightforward framework to inform lighting design and practice.

Non-visual effects of light: how to use light to promote circadian entrainment and elicit alertness.

Abstract: In addition to stimulating the visual system, light incident on the retina stimulates other biological functions, also referred to as non-visual responses. Among the most notable biological functions are human circadian rhythms, which are bodily rhythms that, in constant darkness, oscillate with a period close to, but typically slightly longer than 24 hours. Twenty-four-hour light-dark patterns incident on the retina are the major synchronizer of circadian rhythms to the local time on Earth. Entrainment of circadian rhythms has been implicated in health and well-being. Light can also elicit an acute alerting effect on people, similar to a "cup of coffee." This review summarizes the literature on how light affects entrainment and alertness and how it can be used to achieve these aims.

Performance assessment of commercial circadian personal exposure devices

Abstract: Through the influence on circadian rhythms, natural and artificial lighting, as well as lifestyle and architecture, affect health and performance. Epidemiological and interventional studies of light-initiated circadian biological outcomes require robust 24‐hour data on personal light exposures, including blue light weighted irradiance data. The performance of the detection systems used is a key factor. We assessed the performance of 16 Actiwatch Spectrum™ devices for spectral response, directional response and dynamic range and propose techniques for calibration, deployment and data analysis for use of the watches in circadian studies. The results are presented, followed by a discussion of applicability focussing on spectral response for circadian studies.

The Analysis of Time Series: An Introduction

Abstract: The Analysis of Time Series: An Introduction, 4th edn. By C. Chatfield. ISBN 0 412 31820 2. Chapman and Hall, London, 1989. 242 pp. £13.50.

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness

Abstract: In the past 50 y, there has been a decline in average sleep duration and quality, with adverse consequences on general health. A representative survey of 1,508 American adults recently revealed that 90% of Americans used some type of electronics at least a few nights per week within 1 h before bedtime. Mounting evidence from countries around the world shows the negative impact of such technology use on sleep. This negative impact on sleep may be due to the short-wavelength–enriched light emitted by these electronic devices, given that artificial-light exposure has been shown experimentally to produce alerting effects, suppress melatonin, and phase-shift the biological clock. A few reports have shown that these devices suppress melatonin levels, but little is known about the effects on circadian phase or the following sleep episode, exposing a substantial gap in our knowledge of how this increasingly popular technology affects sleep. Here we compare the biological effects of reading an electronic book on a light-emitting device (LE-eBook) with reading a printed book in the hours before bedtime. Participants reading an LE-eBook took longer to fall asleep and had reduced evening sleepiness, reduced melatonin secretion, later timing of their circadian clock, and reduced nextmorning alertness than when reading a printed book. These results demonstrate that evening exposure to an LE-eBook phase-delays the circadian clock, acutely suppresses melatonin, and has important implications for understanding the impact of such technologies on sleep, performance, health, and safety.

Melatonin: Exceeding Expectations

Abstract: Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.

Effects of Blue Light on the Circadian System and Eye Physiology

Abstract: Light-emitting diodes (LEDs) have been used to provide illumination in industrial and commercial environments. LEDs are also used in TVs, computers, smart phones, and tablets. Although the light emitted by most LEDs appears white, LEDs have peak emission in the blue light range (400-490 nm). The accumulating experimental evidence has indicated that exposure to blue light can affect many physiologic functions, and it can be used to treat circadian and sleep dysfunctions. However, blue light can also induce photoreceptor damage. Thus, it is important to consider the spectral output of LED-based light sources to minimize the danger that may be associated with blue light exposure. In this review, we summarize the current knowledge of the effects of blue light on the regulation of physiologic functions and the possible effects of blue light exposure on ocular health.