L
Lutz Schomburg
Researcher at Humboldt University of Berlin
Publications - 280
Citations - 11307
Lutz Schomburg is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Selenoprotein & Selenoprotein P. The author has an hindex of 55, co-authored 241 publications receiving 9119 citations. Previous affiliations of Lutz Schomburg include Brigham and Women's Hospital & International Agency for Research on Cancer.
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Journal ArticleDOI
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.
Loredana Saveanu,Oliver Carroll,Vivian Lindo,Margarita Del Val,Daniel López,Yves Lepelletier,Fiona M. Greer,Lutz Schomburg,Doriana Fruci,Gabriele Niedermann,Peter van Endert +10 more
TL;DR: The human endoplasmic reticulum is equipped with a pair of trimming aminopeptidases that have complementary functions in HLA class I peptide presentation, and it is shown here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme.
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Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues
Lutz Schomburg,Ulrich Schweizer,Bettina Holtmann,Leopold Flohé,Michael Sendtner,Josef Köhrle +5 more
TL;DR: The data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues and thatSelenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly.
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Mutations in SECISBP2 result in abnormal thyroid hormone metabolism.
Alexandra M. Dumitrescu,Xiao Hui Liao,Mohamed S.Y. Abdullah,Joaquin Lado-Abeal,Joaquin Lado-Abeal,Fathia Abdul Majed,Lars C. Moeller,Gerard Boran,Lutz Schomburg,Roy E. Weiss,Samuel Refetoff +10 more
TL;DR: Systematic linkage analysis of genes involved in DIO2 synthesis and degradation led to the identification of an inherited Sec incorporation defect, caused by a homozygous missense mutation in SECISBP2 (also called SBP2), which had a generalized effect on selenoproteins.
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Selenium, selenoproteins and the thyroid gland: interactions in health and disease
TL;DR: The baseline selenium status of an individual could constitute the most important parameter modifying the outcome of selenum supplementation, which might primarily disrupt self-amplifying cycles of the endocrine–immune system interface rectifying the interaction of lymphocytes with thyroid autoantigens.
Journal ArticleDOI
Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study
Ben Schöttker,Ulrike Haug,Lutz Schomburg,Joseph Köhrle,Laura Perna,Heiko Müller,Bernd Holleczek,Hermann Brenner +7 more
TL;DR: In this large cohort study, serum 25(OH)D concentrations were inversely associated with all-cause and cause-specific mortality, and vitamin D deficiency was strongly associated with mortality from all causes, cardiovascular diseases, cancer, and respiratory diseases.