L
Lydia Michaut
Researcher at Novartis
Publications - 19
Citations - 5302
Lydia Michaut is an academic researcher from Novartis. The author has contributed to research in topics: Gene & Drosophila Protein. The author has an hindex of 12, co-authored 17 publications receiving 5018 citations. Previous affiliations of Lydia Michaut include Centre national de la recherche scientifique & University of Basel.
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Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
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A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
Bruno Lemaitre,Elisabeth Kromer-Metzger,Lydia Michaut,Emmanuelle Nicolas,Marie Meister,Philippe Georgel,Jean-Marc Reichhart,Jules A. Hoffmann +7 more
TL;DR: It is reported that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background, and the results point to the existence of two different pathways leading to the expression of two types of target genes.
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Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides.
Pascale Fehlbaum,Philippe Bulet,Lydia Michaut,Marie Lagueux,Willem F. Broekaert,Charles Hetru,Jules A. Hoffmann +6 more
TL;DR: A novel inducible peptide, which is proposed to name drosomycin, shows a significant homology with a family of 5-kDa cysteine-rich plant antifungal peptides recently isolated from seeds of Brassicaceae, underlines that plants and insects can rely on similar molecules in their innate host defense.
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A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
Dominique Ferrandon,Alain C. Jung,M.-C. Criqui,Bruno Lemaitre,Sandrine Uttenweiler-Joseph,Lydia Michaut,Jean-Marc Reichhart,Jules A. Hoffmann +7 more
TL;DR: It is shown that in addition to the fat body, a variety of epithelial tissues that are in direct contact with the external environment, including those of the respiratory, digestive and reproductive tracts, can express the antifungal peptide, suggesting a local response to infections affecting these barrier tissues.
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Analysis of the eye developmental pathway in Drosophila using DNA microarrays
TL;DR: 371 genes that are expressed in the eye imaginal discs and up-regulated when an eye morphogenetic field is ectopically induced in the leg discs are identified.