The nature of metal complexes of heterocyclic thiosemicarbazones reported in the literature through 1989 have been reviewed with an emphasis on variations in stoichiometry and stereochemistry. A brief introduction is followed by a survey of the biological activity of the uncomplexed thiosemicarbazones. Next is a section on the chemical nature of thiosemicarbazones including a discussion of preparative methods, modes of coordination and isomerism. This is followed by a discussion of structural information and biological activity of the iron(III), iron(II), copper(II), cobalt(III), cobalt(II) and nickel(II) complexes of heterocyclic thiosemicarbazones. Short sections on the biological activity of other chelating thiosemicarbazones and metal complexes are also included.

Structural and physical correlations in the biological properties of transition metal heterocyclic thiosemicarbazone and S -alkyldithiocarbazate complexes

The aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones compounds. The minimal inhibitory concentration (MIC) of these compounds against Mycobacterium tuberculosis was determined. Their in vitro cytotoxicity to J774 cells (IC50) was determined to establish a selectivity index (SI) (SI=IC50/MIC). The best compounds were the thiosemicarbazones (2, 3 and 4) and the hydrazide/hydrazones (14, 15, 16 and 18). The results are comparable to or better than those of "first line" or "second line" drugs commonly used to treat TB, suggesting these compounds as anti-TB drug candidates.

Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/ hydrazones: Anti - Mycobacterium tuberculosis activity and cytotoxicity

Epr, cyclic voltammetric and biological activities of copper(II) complexes of salicylaldehyde N(4)-substituted thiosemicarbazone and heterocyclic bases

Biological activity of palladium(II) and platinum(II) complexes of the acetone Schiff bases of S-methyl- and S-benzyldithiocarbazate and the X-ray crystal structure of the [Pd(asme)2] (asme=anionic form of the acetone Schiff base of S-methyldithiocarbazate) complex.

Metal complexes of saccharin

Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing Schiff bases derived from S-benzyldithiocarbazate and saccharinate ligand and the X-ray crystal structure of the copper-saccharinate complex containing S-benzyl-β-N-(acetylpyrid-2-yl)methylenedithiocarbazate

Synthesis and characterization of some new nickel(II), zinc(II) and cadmium(II) complexes of quadridentate SNNS ligands

Synthesis, characterization and fungitoxicities of metal chelates of a pentadentate N3S2 ligand

Four- and five-coordinate copper(II) complexes containing mixed ligands

Transition metal complexes of furfural and benzil schiff bases derived from S-benzyldithiocarbazate

M.Akbar Ali

Papers

Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing Schiff bases derived from S-benzyldithiocarbazate and saccharinate ligand and the X-ray crystal structure of the copper-saccharinate complex containing S-benzyl-β-N-(acetylpyrid-2-yl)methylenedithiocarbazate

Synthesis and characterization of some new nickel(II), zinc(II) and cadmium(II) complexes of quadridentate SNNS ligands

Synthesis, characterization and fungitoxicities of metal chelates of a pentadentate N3S2 ligand

Four- and five-coordinate copper(II) complexes containing mixed ligands

Transition metal complexes of furfural and benzil schiff bases derived from S-benzyldithiocarbazate