M. C. Knight

TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.

TL;DR: This work shows the first evidence that the developmental growth plate in mammals is hypoxic, and that this hypoxia occurs in its interior rather than at its periphery, and finds that VEGF expression in the growth plate is regulated through both HIF-1alpha-dependent and -independent mechanisms.

TL;DR: These findings identify the PPR as a crucial mediator of both bone-forming and bone-resorbing actions of PTH, and underline the complexity and heterogeneity of the osteoblast population and/or their regulatory microenvironment.

TL;DR: This is the first study reporting the novel and intriguing findings that pVHL has a crucial role in endochondral bone development and is necessary for normal chondrocyte proliferation in vivo.

TL;DR: The data suggest that odontoblastic activation of the PPR may play an important role in terminal odontobastic and, indirectly, ameloblastic cytodifferentiation, and describe a useful model to study how this novel action of thePPR may modulate mesenchymal/epithelial interactions at later stages of tooth morphogenesis and development.