M
M. Dempster
Researcher at University of Edinburgh
Publications - 18
Citations - 3814
M. Dempster is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Locus (genetics) & Telomere. The author has an hindex of 13, co-authored 18 publications receiving 3715 citations. Previous affiliations of M. Dempster include Western General Hospital.
Papers
More filters
Journal ArticleDOI
Telomere reduction in human colorectal carcinoma and with ageing
Nicholas D. Hastie,M. Dempster,Malcolm G. Dunlop,Alastair M. Thompson,Daryll K. Green,Robin C. Allshire,Robin C. Allshire +6 more
TL;DR: It is shown that in most of the colorectal carcinomas that were analysed, there is a reduction in the length of telomere repeat arrays relative to the normal colonic mucosa from the same patient, and it is proposed that the telomerase2–4 is inactive in somatic tissues, andTelomere length is an indicator of the number of cell divisions that it has taken to form a particular tissue and possibly to generate tumours.
Journal ArticleDOI
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
Martine Migaud,Paul Charlesworth,M. Dempster,Lorna C. Webster,Ayako M. Watabe,Michael Makhinson,Yong He,M. Ramsay,Richard G. M. Morris,John H. Morrison,Thomas J. O'Dell,Seth G. N. Grant +11 more
TL;DR: In mutant mice lacking PSD-95, the frequency function of NMDA-dependent LTP and LTD is shifted to produce strikingly enhanced LTP at different frequencies of synaptic stimulation, which is accompanied by severely impaired spatial learning.
Journal ArticleDOI
Human telomeres contain at least three types of G-rich repeat distributed non-randomly
TL;DR: It is demonstrated here that human telomeres do not contain a pure uniform 6 base pair repeat unit but that there are at least three types of repeat, which are present at the ends of most or all human chromosomes.
Journal ArticleDOI
Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.
Otto Windl,M. Dempster,J. P. Estibeiro,Richard Lathe,R de Silva,T.F.G. Esmonde,Robert G. Will,Anthea Springbett,T. A. Campbell,Katie C. L. Sidle,M. S. Palmer,John Collinge +11 more
TL;DR: A reliable estimate of the incidence of PRNP-related inherited CJD is calculated based on a prospective epidemiological series and it is confirmed that the genotype distribution with respect to the common methionine/valine (Met/Val) polymorphism at codon 129 within PRNP was significantly different from the normal Caucasian population.
Journal Article
Heterogeneity Analysis in 40 X-linked Retinitis Pigmentosa Families
P. W. Teague,M. A. Aldred,Marcelle Jay,M. Dempster,C. Harrison,Andrew D. Carothers,L. J. Hardwick,H. J. Evans,L. Strain,David J. H. Brock,S. Bundey,Barrie Jay,A C Bird,Ss Bhattacharya,Alan F. Wright +14 more
TL;DR: Analysis of genetic heterogeneity in 40 kindreds with X-linked retinitis pigmentosa (XLRP), with 20 polymorphic markers, showed that significant heterogeneity is present (P = .001) and that 56% of kindreds are of RP3 type and that 26% are ofRP2 type.