M
M. Isabel Lucena
Researcher at University of Málaga
Publications - 155
Citations - 7081
M. Isabel Lucena is an academic researcher from University of Málaga. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 37, co-authored 113 publications receiving 5658 citations. Previous affiliations of M. Isabel Lucena include University of Valladolid & Carlos III Health Institute.
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Journal ArticleDOI
Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more
TL;DR: Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation, and amoxicillin-clavulanate stands out as the most common drug related to DILI.
Journal ArticleDOI
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury is Influenced by Multiple HLA Class I and II Alleles
M. Isabel Lucena,Mariam Molokhia,Yufeng Shen,Thomas J. Urban,Guruprasad P. Aithal,Raúl J. Andrade,Christopher Day,Francisco Ruiz-Cabello,Peter T. Donaldson,Camilla Stephens,Munir Pirmohamed,Manuel Romero-Gómez,J.M. Navarro,Robert J. Fontana,Michael H Miller,Max Groome,Emmanuelle Bondon-Guitton,Anita Conforti,Bruno H. Ch. Stricker,Alfonso Carvajal,Luisa Ibáñez,Qun-Ying Yue,Michel Eichelbaum,Aris Floratos,Itsik Pe'er,Mark J. Daly,David Goldstein,John F. Dillon,Matthew R. Nelson,Paul B. Watkins,Ann K. Daly +30 more
TL;DR: Class I and II HLA genotypes affect susceptibility to AC-DILI, indicating the importance of the adaptive immune response in pathogenesis.
Journal ArticleDOI
Drug-induced liver injury
Raúl J. Andrade,Naga Chalasani,Einar Bjornsson,Ayako Suzuki,Ayako Suzuki,Gerd A. Kullak-Ublick,Gerd A. Kullak-Ublick,Paul B. Watkins,Harshad Devarbhavi,Michael Merz,Michael Merz,M. Isabel Lucena,Neil Kaplowitz,Guruprasad P. Aithal +13 more
TL;DR: Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use as discussed by the authors.
Journal ArticleDOI
Drug-induced liver injury: Interactions between drug properties and host factors
TL;DR: Current knowledge on 1) drug properties associated with hepatotoxicity, 2) host factors considered to modify an individuals' risk for DILI and clinical phenotypes, and 3) drug-host interactions are summarized.
Journal ArticleDOI
Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry
Raúl J. Andrade,M. Isabel Lucena,Neil Kaplowitz,Beatriz García‐Muņoz,Y. Borraz,Ketevan Pachkoria,Miren García-Cortés,M. Carmen Fernández,G. Pelaez,Luis Rodrigo,José Antonio Durán,Joan Costa,Ramon Planas,A.M. Barriocanal,Carlos Guarner,Manuel Romero-Gómez,Teresa Muņoz‐Yagüe,Javier Salmerón,Ramón Hidalgo +18 more
TL;DR: Patients with cholestatic/mixed injury were more prone to chronicity than patients with hepatocellular injury, and cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage.