M
M. J. Owen
Researcher at Imperial College London
Publications - 6
Citations - 4687
M. J. Owen is an academic researcher from Imperial College London. The author has contributed to research in topics: Chromosome 21 & Molecular genetics. The author has an hindex of 5, co-authored 6 publications receiving 4555 citations.
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Segregation of a missense mutation in the amyloid precursor protein gene with familial alzheimers-disease
A. Goate,M-C. Chartier-Harlin,Michael Mullan,J Brown,Fiona Crawford,Liana Fidani,L Giuffra,A. Haynes,N Irving,L James,R Mant,P. J. Newton,K Rooke,P Roques,C. Conover Talbot,Pericak-Vance Margareta A,A. Roses,Robert Williamson,Martin N. Rossor,M. J. Owen,John Hardy +20 more
TL;DR: It is demonstrated that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene that causes an amino-acid substitution close to the carboxy terminus of the β-amyloid peptide.
Journal ArticleDOI
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
P. St. George-Hyslop,Jonathan L. Haines,Lindsay A. Farrer,Ronald J. Polinsky,C. Van Broeckhoven,Alison Goate,D. R. Crapper McLachlan,Harry T. Orr,Amalia C. Bruni,Sandro Sorbi,Innocenzo Rainero,J. F. Foncin,Daniel A. Pollen,J. M. Cantu,Rossella Tupler,Rossella Tupler,Voskresenskaya Ni,Richard Mayeux,John H. Growdon,V. A. Fried,Richard H. Myers,Linda Nee,H Backhovens,J. J. Martin,Martin N. Rossor,M. J. Owen,Michael Mullan,M. E. Percy,H. Karlinsky,Stephen S. Rich,Leonard L. Heston,M.P. Montesi,M. Mortilla,N. Nacmias,James F. Gusella,John Hardy,K. Abe,Luigi Amaducci,L. Bergamini,Marc Bruyland,Stefano F. Cappa,Stefano F. Cappa,L. Connor,G. De Winter,David A. Drachman,Robert G. Feldman,M. Fracarro,M. Fracarro,M. E. Franco,P. Frommelt,Gavrilova Si,G. Gei,J. Gheuens,A. Haynes,J. Henry,L James,Marianne James,B. O'Donnell,Silvia Piacentini,L. Pinessi,P Roques,C. Ruiz,J. Swearer,Rudolph E. Tanzi,Antoon Vandenberghe,M. Vartanian,G. Vaula,Paul C. Watkins,Robert Williamson +68 more
TL;DR: The inheritance of five polymorphic DNA markers from the proximal long arm of chromosome 21 in a large unselected series of pedi-grees with familial Alzheimer's disease suggests that Alzheimer's Disease is not a single entity, but rather results from genetic defects on chromosome 21 and from other genetic or nongenetic factors.
The molecular-genetics of alzheimers-disease
Ja Hardy,M. J. Owen,Am Goate,L James,A. Haynes,Robert Williamson,P Roques,Mn Rossor,Mj Mullan +8 more