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M.-M. López-Murcia

Bio: M.-M. López-Murcia is an academic researcher. The author has contributed to research in topics: Lens (optics) & Ultraviolet. The author has an hindex of 1, co-authored 1 publications receiving 6 citations.

Papers
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Journal ArticleDOI
TL;DR: The mean spectral transmission curve of the crystalline lens of the pig lens appears to be similar to that of the human lens in the visible spectrum, but different in the ultraviolet.
Abstract: Summary Objective To determine the spectral transmission curve of the crystalline lens of the pig. To analyse how this curve changes when the crystalline lens is irradiated with ultraviolet A + B radiation similar to that of the sun. To compare these results with literature data from the human crystalline lens. Procedures We used crystalline lenses of the common pig from a slaughterhouse, i.e. genetically similar pigs, fed with the same diet, and slaughtered at six months old. Spectral transmission was measured with a Perkin-Elmer Lambda 35 UV/VIS spectrometer. The lenses were irradiated using an Asahi Spectra Lax-C100 ultraviolet source, which made it possible to select the spectral emission band as well as the intensity and exposure time. Results The pig lens transmits all the visible spectrum (95%) and lets part of the ultraviolet A through (15%). Exposure to acute UV (A + B) irradiation causes a decrease in its transmission as the intensity or exposure time increases: this decrease is considerable in the UV region. Conclusions We were able to determine the mean spectral transmission curve of the pig lens. It appears to be similar to that of the human lens in the visible spectrum, but different in the ultraviolet. Pig lens transmission is reduced by UV (A + B) irradiation and its transmission in the UV region can even disappear as the intensity or exposure time increases. An adequate exposure intensity and time of UV (A + B) radiation always causes an anterior subcapsular cataract (ASC).

7 citations


Cited by
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Journal ArticleDOI
TL;DR: A non-comprehensive overview of recent developments regarding effects of solar UV radiation wavebands on the lens and the isolated or combined temporal and spatial effects of UVA and UVB in the pathogenesis of human cataract.

56 citations

Journal ArticleDOI
TL;DR: This review aims to revisit the effect of UV radiation on cataracts categorizing the cellular pathways involved and provide an overview of the protecting agents utilized as UV shields.
Abstract: The magnitude of cataract pathology is indeed significant as it is the principal cause of blindness worldwide. Also, the prominence of this concept escalates with the current aging population. The burden of the disease is more tangible in developing countries than developed ones. Regarding this concern, there is a gap in classifying the pathogenesis of the ultraviolet (UV) radiation-induced cataracts and explaining the possible cellular and subcellular pathways. In this review, we aim to revisit the effect of UV radiation on cataracts categorizing the cellular pathways involved. This may help for better pharmaceutical treatment alternatives and their wide-reaching availability. Also, in the last section, we provide an overview of the protecting agents utilized as UV shields. Further studies are required to enlighten new treatment modalities for UV radiation-induced pathologies in human lens.

16 citations

Journal ArticleDOI
TL;DR: In this paper, the impact of the blue visible light in porcine lens compared to UVA and UVB radiation was investigated, and it was shown that the 460 nm irradiation causes the most cataract.
Abstract: Background and Objectives: Cataract is still the leading cause of blindness. Its development is well researched for UV radiation. Modern light sources like LEDs and displays tend to emit blue light. The effect of blue light on the retina is called blue light hazard and is studied extensively. However, its impact on the lens is not investigated so far. Aim: Investigation of the impact of the blue visible light in porcine lens compared to UVA and UVB radiation. Materials and Methods: In this ex-vivo experiment, porcine lenses are irradiated with a dosage of 6 kJ/cm2 at wavelengths of 311 nm (UVB), 370 nm (UVA), and 460 nm (blue light). Lens transmission measurements before and after irradiation give insight into the impact of the radiation. Furthermore, dark field images are taken from every lens before and after irradiation. Cataract development is illustrated by histogram linearization as well as faults coloring of recorded dark field images. By segmenting the lens in the background's original image, the lens condition before and after irradiation could be compared. Results: All lenses irradiated with a 6 kJ/cm2 reveal cataract development for radiation with 311 nm, 370 nm, and 460 nm. Both evaluations reveal that the 460 nm irradiation causes the most cataract. Conclusion: All investigated irradiation sources cause cataracts in porcine lenses-even blue visible light.

8 citations

Journal ArticleDOI
TL;DR: The authors suggest that in the lens rare molecules of the damaged protein interact with undissociated oligomers of α-crystallin, and thus preventing aggregation, and so preventing aggregation.

6 citations

Journal ArticleDOI
TL;DR: This method, however, does not make it possible to ascertain whether the scattering measured is caused by surface light scattering or internal light scattering, and is checked by measuring the scattering of three explanted IOLs from cornea donors.
Abstract: This study presents a method for measuring scattering in explanted intraocular lenses (IOLs). Currently, determining scattering in IOLs is usually performed by Scheimpflug cameras and the results are expressed in the units used by this apparatus. The method we propose uses a spectrophotometer and this makes it possible to measure the total transmission of the IOL by using an integrating sphere; the direct transmission is determined by the double-beam mode. The difference between these two transmissions gives a value of the scattering in percentage values of light lost. In addition, by obtaining the spectral transmission curve, information about the most scattered wavelengths is also obtained. The IOL power introduces errors when directly measured, particularly with high powers. This problem can be overcome if a tailor-made cuvette is used that shortens the distance between the IOL and the condensing lens of the spectrophotometer when the IOL powers are below 24 diopters. We checked the effectiveness of this method by measuring the scattering of three explanted IOLs from cornea donors. This method, however, does not make it possible to ascertain whether the scattering measured is caused by surface light scattering or internal light scattering.

2 citations