M
M. Todd Valerius
Researcher at Brigham and Women's Hospital
Publications - 52
Citations - 8307
M. Todd Valerius is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Progenitor cell & Nephron. The author has an hindex of 27, co-authored 49 publications receiving 7001 citations. Previous affiliations of M. Todd Valerius include Cincinnati Children's Hospital Medical Center & Hospital Research Foundation.
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Journal ArticleDOI
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Benjamin D. Humphreys,Benjamin D. Humphreys,Shuei-Liong Lin,Shuei-Liong Lin,Akio Kobayashi,Thomas E. Hudson,Brian T. Nowlin,Joseph V. Bonventre,Joseph V. Bonventre,M. Todd Valerius,Andrew P. McMahon,Jeremy S. Duffield,Jeremy S. Duffield +12 more
TL;DR: Data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.
Journal ArticleDOI
Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development
Akio Kobayashi,M. Todd Valerius,Joshua W. Mugford,Thomas L. Carroll,Michelle Self,Guillermo Oliver,Andrew P. McMahon +6 more
TL;DR: Clonal analysis indicates that at least some Six2-expressing cells are multipotent, contributing to multiple domains of the nephron, and observations suggest that Six2 activity cell-autonomously regulates a multipotent nephrons progenitor population.
Journal ArticleDOI
Intrinsic Epithelial Cells Repair the Kidney after Injury
Benjamin D. Humphreys,Benjamin D. Humphreys,M. Todd Valerius,Akio Kobayashi,Joshua W. Mugford,Savuth Soeung,Jeremy S. Duffield,Andrew P. McMahon,Joseph V. Bonventre,Joseph V. Bonventre,Joseph V. Bonventre +10 more
TL;DR: Results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney.
Journal ArticleDOI
Nephron organoids derived from human pluripotent stem cells model kidney development and injury
Ryuji Morizane,Ryuji Morizane,Albert Q. Lam,Albert Q. Lam,Benjamin S. Freedman,Benjamin S. Freedman,Seiji Kishi,Seiji Kishi,M. Todd Valerius,M. Todd Valerius,Joseph V. Bonventre,Joseph V. Bonventre +11 more
TL;DR: An efficient, chemically defined protocol for differentiating hPSCs into multipotent nephrons progenitor cells (NPCs) that can form nephron-like structures that can be used to study mechanisms of human kidney development and toxicity is reported.
Journal ArticleDOI
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Benjamin S. Freedman,Craig R. Brooks,Albert Q. Lam,Albert Q. Lam,Hongxia Fu,Ryuji Morizane,Vishesh Agrawal,Abdelaziz F. Saad,Michelle Li,Michelle Li,Michael R. Hughes,Ryan Vander Werff,Derek T. Peters,Derek T. Peters,Junjie Lu,Anna Baccei,Andrew M. Siedlecki,M. Todd Valerius,M. Todd Valerius,Kiran Musunuru,Kiran Musunuru,Kelly M. McNagny,Theodore I. Steinman,Theodore I. Steinman,Jing Zhou,Jing Zhou,Paul H. Lerou,Paul H. Lerou,Joseph V. Bonventre,Joseph V. Bonventre +29 more
TL;DR: It is shown that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing, establishing a reproducible, versatile three-dimensional framework for human epithelial disease modelling and regenerative medicine applications.