M. Y. Jaffrin

Bio: M. Y. Jaffrin is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Reynolds number & Wavelength. The author has an hindex of 6, co-authored 7 publications receiving 2492 citations.

Peristaltic pumping with long wavelengths at low Reynolds number

Abstract: Pumping by means of an infinite train of peristaltic waves is investigated under conditions for which the relevant Reynolds number is small enough for inertial effects to be negligible and the wavelength to diameter ratio is large enough for the pressure to be considered uniform over the cross-section. Theoretical results are presented for both plane and axisymmetric geometries, and for amplitude ratios ranging from zero to full occlusion. For a given amplitude ratio, the theoretical pressure rise per wavelength decreases linearly with increasing time-mean flow. An experiment with a quasi-two-dimensional apparatus confirmed the theoretical values.Calculations of the detailed fluid motions reveal that under many conditions of operation the net time-mean flow is the algebraic difference between a forward time-mean flow in the core of the tube and a backward (‘reflux’) time-mean flow near the periphery. The percentage of reflux flow can be very high. This reflux phenomenon is probably of physiologic significance in the functioning of the ureter and the gastro-intestinal system. A second fluid-mechanical peculiarity with physiological implications is that of ‘trapping’: under certain conditions an internally circulating bolus of fluid, lying about the axis, is transported with the wave speed as though it were trapped by the wave.

Peristaltic pumping with long wave lengths at low reynolds number.

Abstract: : Pumping by means of an infinite train of peristaltic waves is investigated under conditions for which (1) the relevant Reynolds number is small enough for inertial effects to be negligible and (2) the wavelength-diameter ratio is large enough for the pressure to be considered uniform over the cross-section. Theoretical results are presented for both plane and axi-symmetric geometries, and for amplitude ratios ranging from zero to full occlusion. For a given amplitude ratio, the theoretical pressure rise per wavelength decreases linearly with increasing time-mean flow. An experiment with a quasi-two-dimensional apparatus confirmed the theoretical values. Calculations of the detailed fluid motions reveal that under many conditions of operation the net time-mean flow is the algebraic difference between a forward time-mean flow in the core of the tube and a backward ('reflux') time-mean flow near the periphery. The percentage of reflux flow can be very high. This reflux phenomenon is probably of physiologic significance in the functioning of the ureter and the gastro-intestinal system. A second fluid mechanical peculiarity with physiological implications is that of 'trapping': under certain conditions an internally-circulating bolus of fluid, lying about the axis, is transported with the wave speed as though it were trapped by the wave. (Author)

Validation of a one-dimensional model of the systemic arterial tree.

Abstract: A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughout the systemic arterial tree. Intimal shear is modeled using the Witzig-Womersley theory. A nonlinear viscoelastic constitutive law for the arterial wall is considered. The left ventricle is modeled using the varying elastance model. Distal vessels are terminated with three-element windkessels. Coronaries are modeled assuming a systolic flow impediment proportional to ventricular varying elastance. Arterial dimensions were taken from previous 1-D models and were extended to include a detailed description of cerebral vasculature. Elastic properties were taken from the literature. To validate model predictions, noninvasive measurements of pressure and flow were performed in young volunteers. Flow in large arteries was measured with MRI, cerebral flow with ultrasound Doppler, and pressure with tonometry. The resulting 1-D model is the most complete, because it encompasses all major segments of the arterial tree, accounts for ventricular-vascular interaction, and includes an improved description of shear stress and wall viscoelasticity. Model predictions at different arterial locations compared well with measured flow and pressure waves at the same anatomical points, reflecting the agreement in the general characteristics of the "generic 1-D model" and the "average subject" of our volunteer population. The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation.

Structured tree outflow condition for blood flow in larger systemic arteries

Abstract: A central problem in modeling blood flow and pressure in the larger systemic arteries is determining a physiologically based boundary condition so that the arterial tree can be truncated after a few generations. We have used a structured tree attached to the terminal branches of the truncated arterial tree in which the root impedance is estimated using a semianalytical approach based on a linearization of the viscous axisymmetric Navier-Stokes equations. This provides a dynamic boundary condition that maintains the phase lag between blood flow and pressure as well as the high-frequency oscillations present in the impedance spectra. Furthermore, it accommodates the wave propagation effects for the entire systemic arterial tree. The result is a model that is physiologically adequate as well as computationally feasible. For validation, we have compared the structured tree model with a pure resistance and a windkessel model as well as with measured data.