M
Madhusudan Grover
Researcher at Mayo Clinic
Publications - 143
Citations - 4824
Madhusudan Grover is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Gastroparesis & Gastric emptying. The author has an hindex of 33, co-authored 119 publications receiving 3241 citations. Previous affiliations of Madhusudan Grover include Michigan State University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Cellular changes in diabetic and idiopathic gastroparesis.
Madhusudan Grover,Gianrico Farrugia,Matthew S. Lurken,Cheryl E. Bernard,Maria Simonetta Faussone Pellegrini,Thomas C. Smyrk,Henry P. Parkman,Thomas L. Abell,William J. Snape,William L. Hasler,Aynur Unalp–Arida,Linda Nguyen,Kenneth L. Koch,J. Calles,Linda Lee,James Tonascia,Frank A. Hamilton,Pankaj J. Pasricha +17 more
TL;DR: It is suggested that on full-thickness biopsy specimens, cellular abnormalities are found in the majority of patients with gastroparesis, and an increase in CD45 and CD68 immunoreactivity is found.
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Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis
Fabiane B. Klem,Fabiane B. Klem,Akhilesh Wadhwa,Larry J. Prokop,Wendy Sundt,Gianrico Farrugia,Michael Camilleri,Siddharth Singh,Madhusudan Grover +8 more
TL;DR: In a systematic review and meta-analysis, it is found >10% of patients with infectious enteritis develop IBS later; risk of IBS was 4-fold higher than in individuals who did not have infectiousEnteritis, although there was heterogeneity among studies analyzed.
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Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
Yogesh Bhattarai,Brianna B. Williams,Eric J. Battaglioli,Weston R. Whitaker,Lisa Till,Madhusudan Grover,David R. Linden,Yasutada Akiba,Karunya K. Kandimalla,Nicholas C. Zachos,Jonathan D. Kaunitz,Justin L. Sonnenburg,Michael A. Fischbach,Gianrico Farrugia,Purna C. Kashyap +14 more
TL;DR: This study demonstrates an aspect of host physiology under control of a bacterial metabolite that can be exploited as a therapeutic modality through the 5-HT4 receptor, a G-protein-coupled receptor uniquely expressed in the colonic epithelium.
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Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
Ruben A. T. Mars,Yi Yang,Tonya Ward,Mo Houtti,Sambhawa Priya,Heather Lekatz,Xiaojia Tang,Zhifu Sun,Krishna R. Kalari,Tal Korem,Tal Korem,Yogesh Bhattarai,Tenghao Zheng,Noam Bar,Gary Frost,Abigail J. Johnson,Will Van Treuren,Shuo Han,Tamas Ordog,Madhusudan Grover,Justin L. Sonnenburg,Mauro D'Amato,Michael Camilleri,Eran Elinav,Eran Segal,Ran Blekhman,Gianrico Farrugia,Jonathan R. Swann,Jonathan R. Swann,Dan Knights,Purna C. Kashyap +30 more
TL;DR: This study integrated longitudinal multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of irritable bowel syndrome (IBS) host physiology to identify functional mechanisms that can serve as therapeutic targets in a comprehensive treatment strategy for chronic GI diseases.
Journal ArticleDOI
Clinical-histological associations in gastroparesis: results from the Gastroparesis Clinical Research Consortium.
Madhusudan Grover,Cheryl E. Bernard,Pankaj J. Pasricha,Matthew S. Lurken,Maria-Simonetta Faussone-Pellegrini,Thomas C. Smyrk,Henry P. Parkman,Thomas L. Abell,William J. Snape,William L. Hasler,Richard W. McCallum,Linda Nguyen,K. L. Koch,J. Calles,Lauren A. Lee,James Tonascia,Aynur Unalp-Arida,Frank A. Hamilton,Gianrico Farrugia +18 more
TL;DR: In this article, the authors found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both diabetic and idiopathic gastroparesis patients.