M
Magda Bienko
Researcher at Science for Life Laboratory
Publications - 40
Citations - 2926
Magda Bienko is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 14, co-authored 23 publications receiving 2130 citations. Previous affiliations of Magda Bienko include Massachusetts Institute of Technology & Goethe University Frankfurt.
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Journal ArticleDOI
Integrated genome and transcriptome sequencing of the same cell
Siddharth S. Dey,Siddharth S. Dey,Lennart Kester,Lennart Kester,Bastiaan Spanjaard,Bastiaan Spanjaard,Magda Bienko,Magda Bienko,Magda Bienko,Alexander van Oudenaarden,Alexander van Oudenaarden +10 more
TL;DR: It is found that genes with high cell-to-cell variability in transcript numbers generally have lower genomic copy numbers, and vice versa, suggesting that copy number variations may drive variability in gene expression among individual cells.
Journal ArticleDOI
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
Nicola Crosetto,Abhishek Mitra,Maria Joao Silva,Magda Bienko,Magda Bienko,Norbert Dojer,Norbert Dojer,Qi Wang,Qi Wang,Elif Karaca,Elif Karaca,Roberto Chiarle,Roberto Chiarle,Roberto Chiarle,Magdalena Skrzypczak,Krzysztof Ginalski,Philippe Pasero,Maga Rowicka,Ivan Dikic +18 more
TL;DR: The genomic landscape of sensitivity to replication stress in human cells was characterized, and >2,000 nonuniformly distributed aphidicolin-sensitive regions (ASRs) overrepresented in genes and enriched in satellite repeats were identified.
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A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
Michaela Asp,Stefania Giacomello,Ludvig Larsson,Chenglin Wu,Daniel Fürth,Xiaoyan Qian,Eva Wärdell,Joaquin Custodio,Johan Reimegård,Fredrik Salmén,Cecilia Österholm,Patrik L. Ståhl,Erik Sundström,Elisabet Åkesson,Olaf Bergmann,Magda Bienko,Agneta Månsson-Broberg,Mats Nilsson,Christer Sylvén,Joakim Lundeberg +19 more
TL;DR: A molecular approach is presented that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains.
Journal ArticleDOI
Spatially resolved transcriptomics and beyond
TL;DR: Pioneering technologies that enable spatially resolved transcriptomics are summarized and how these methods have the potential to extend beyond transcriptomics to encompass spatially resolution genomics, proteomics and possibly other omic disciplines are discussed.
Journal ArticleDOI
Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells
Jop Kind,Jop Kind,Ludo Pagie,Sandra S. de Vries,Leila Nahidiazar,Siddharth S. Dey,Magda Bienko,Ye Zhan,Bryan R. Lajoie,Carolyn A. de Graaf,Mario Amendola,Geoffrey Fudenberg,Maxim Imakaev,Leonid A. Mirny,Kees Jalink,Job Dekker,Alexander van Oudenaarden,Bas van Steensel +17 more
TL;DR: The consistency of NL contacts is inversely linked to gene activity in single cells and correlates positively with the heterochromatic histone modification H3K9me3, which highlights fundamental principles of single-cell chromatin organization.