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Magnus Gustafsson

Bio: Magnus Gustafsson is an academic researcher from Chalmers University of Technology. The author has contributed to research in topics: Dipole & Hydrosilylation. The author has an hindex of 25, co-authored 94 publications receiving 1546 citations. Previous affiliations of Magnus Gustafsson include University of Gothenburg & Umeå University.


Papers
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Journal ArticleDOI
TL;DR: In this article, Collision-Induced Absorption (CIA) spectra of N2, H2, O2, CO2, and CH4 due to various collisionally interacting atoms or molecules are presented.
Abstract: This paper describes the addition of Collision-Induced Absorption (CIA) into the HITRAN compilation. The data from different experimental and theoretical sources have been cast into a consistent format and formalism. The implementation of these new spectral data into the HITRAN database is invaluable for modeling and interpreting spectra of telluric and other planetary atmospheres as well as stellar atmospheres. In this implementation for HITRAN, CIAs of N2, H2, O2, CO2, and CH4 due to various collisionally interacting atoms or molecules are presented. Some CIA spectra are given over an extended range of frequencies, including several H2 overtone bands that are dipole-forbidden in the non-interacting molecules. Temperatures from tens to thousands of Kelvin are considered, as required, for example, in astrophysical analyses of objects, including cool white dwarfs, brown dwarfs, M dwarfs, cool main sequence stars, solar and extra-solar planets, and the formation of so-called first stars.

322 citations

Journal ArticleDOI
TL;DR: A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.

113 citations

Patent
09 Jun 2008
TL;DR: In this paper, the authors present a method and a system for facilitating calibration of a robot cell including one or more objects, and an industrial robot performing work in connection to the objects, wherein the robot cell is programmed by means of an off-line programming tool including a graphical component for generating 2D or 3D graphics based on graphical models of the objects.
Abstract: The present invention relates to a method and a system for facilitating calibration of a robot cell including one or more objects (8) and an industrial robot (1,2,3) performing work in connection to the objects, wherein the robot cell is programmed by means of an off-line programming tool including a graphical component for generating 2D or 3D graphics based on graphical models of the objects. The system comprises a computer unit (10) located at the off-line programming site and configured to store a sequence of calibration points for each of the objects, and to generate a sequence of images (4) including graphical representations of the objects to be calibrated and the calibration points in relation to the objects, and to transfer the images to the robot, and that the robot is configured to display said sequence of images to a robot operator during calibration of the robot cell so that for each calibration point a view including the present calibration point and the object to be calibrated is displayed to the robot operator.

99 citations

Journal ArticleDOI
TL;DR: The authors compared students' experiences of two types of criteria-based assessment: in text commentary and rubric-articulated feedback, in an assessment design combining the two feedback channels, and concluded that the different functions have the potential of creating a sufficiently balanced assessment design with the possibility of serving both short-term and continuous learning goals.
Abstract: This study compares students' experiences of two types of criteria-based assessment: in text commentary and rubric-articulated feedback, in an assessment design combining the two feedback channels. The main aim is to use students' responses to shed light on how feedback strategies for formative assessment can be optimised. Following action research methodology, the study discusses key categories of student responses from three sources: reflective texts, a questionnaire, and interviews. Results show that different functions were attributed to the two feedback channels: in-text commentary to lower-order concerns related to language proficiency, and rubric-articulated feedback to higher-order concerns related to an overview of writing achievement. We argue that the different functions have the potential of creating a sufficiently balanced assessment design with the possibility of serving both short-term and continuous learning goals. On the other hand, some students found it difficult to navigate between the two feedback channels. The article therefore ends with a 'lessons learned' section where we list possible ways in which the current assessment design can be improved for optimal use of the synergy effects emanating from a combination of in-text commentary and rubric-articulated feedback for formative purposes.

48 citations

Journal ArticleDOI
TL;DR: These highly efficacious CaSR allosteric agonists represent leads for developing therapeutic agents with potential advantages over existing therapies and compared their pharmacology to phenylalkylamine calcimimetics.
Abstract: We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics. 1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol (AC-265347) activated CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively. (S)-1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol) [(S)-AC-265347], the S-enantiomer of AC-265347, was approximately 10- to 20-fold more potent than (R)-1-benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol) [(R)-AC-265347]. The phenylalkylamines cinacalcet and calindol had activity similar to that of AC-265347 in cellular proliferation assays but less activity in PI assays. All compounds had reduced activity when extracellular Ca(2+) was removed, indicating that they cooperate with Ca(2+) to activate CaSRs, and all activated CaSR isoforms with the N-terminal extracellular domain deleted, indicating that they interact with the transmembrane domains. In both cases, AC-265347 and therefore (S)-AC-265347 were significantly more efficacious than the phenylalkylamines. Mutations E837A(7.39) and I841A(7.43) strongly reduced phenylalkylamine-induced signaling, but not AC-265347- or (S)-AC-265347-induced signaling, suggesting different modes of binding. AC-265347 and (S)-AC-265347 stimulated significantly greater responses than cinacalcet or calindol at each of four loss-of-function human polymorphic CaSR variants. AC-265347 did not inhibit the CYP2D6 cytochrome P450 isozyme, unlike cinacalcet, which is a potent CYP2D6 inhibitor. In rats, AC-265347, (S)-AC-265347, and (R)-AC-265347 each reduced serum parathyroid hormone (PTH) with a rank order potency correlated with their in vitro potencies. AC-265347 and (S)-AC-265347 also reduced plasma ionizable calcium ([Ca(2+)](o)). AC-265347 was orally active, and its plasma concentrations correlated well with its effects on serum PTH. Thus, these highly efficacious CaSR allosteric agonists represent leads for developing therapeutic agents with potential advantages over existing therapies.

46 citations


Cited by
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Journal Article

4,293 citations

Journal ArticleDOI
TL;DR: The Modules for Experiments in Stellar Astrophysics (MESA) Isochrones and Stellar Tracks (MIST) project as discussed by the authors provides a set of stellar evolutionary tracks and isochrones computed using MESA, a state-of-the-art 1D stellar evolution package.
Abstract: This is the first of a series of papers presenting the Modules for Experiments in Stellar Astrophysics (MESA) Isochrones and Stellar Tracks (MIST) project, a new comprehensive set of stellar evolutionary tracks and isochrones computed using MESA, a state-of-the-art open-source 1D stellar evolution package. In this work, we present models with solar-scaled abundance ratios covering a wide range of ages ($5 \leq \rm \log(Age)\;[yr] \leq 10.3$), masses ($0.1 \leq M/M_{\odot} \leq 300$), and metallicities ($-2.0 \leq \rm [Z/H] \leq 0.5$). The models are self-consistently and continuously evolved from the pre-main sequence to the end of hydrogen burning, the white dwarf cooling sequence, or the end of carbon burning, depending on the initial mass. We also provide a grid of models evolved from the pre-main sequence to the end of core helium burning for $-4.0 \leq \rm [Z/H] < -2.0$. We showcase extensive comparisons with observational constraints as well as with some of the most widely used existing models in the literature. The evolutionary tracks and isochrones can be downloaded from the project website at this http URL

1,301 citations

Journal ArticleDOI
TL;DR: The spiro[pyrrolidine-3,3′-oxindole] ring system is found at the core of a number of alkaloids, which possess significant biological activity and are interesting, challenging targets for chemical synthesis as discussed by the authors.

1,267 citations

Journal ArticleDOI
TL;DR: The Modules for Experiments in Stellar Astrophysics (MESA) Isochrones and Stellar Tracks (MIST) project as mentioned in this paper provides a set of stellar evolutionary tracks and isochrones computed using MESA, a state-of-the-art 1D stellar evolution package.
Abstract: This is the first of a series of papers presenting the Modules for Experiments in Stellar Astrophysics (MESA) Isochrones and Stellar Tracks (MIST) project, a new comprehensive set of stellar evolutionary tracks and isochrones computed using MESA, a state-of-the-art open-source 1D stellar evolution package. In this work, we present models with solar-scaled abundance ratios covering a wide range of ages ($5 \leq \rm \log(Age)\;[yr] \leq 10.3$), masses ($0.1 \leq M/M_{\odot} \leq 300$), and metallicities ($-2.0 \leq \rm [Z/H] \leq 0.5$). The models are self-consistently and continuously evolved from the pre-main sequence to the end of hydrogen burning, the white dwarf cooling sequence, or the end of carbon burning, depending on the initial mass. We also provide a grid of models evolved from the pre-main sequence to the end of core helium burning for $-4.0 \leq \rm [Z/H] < -2.0$. We showcase extensive comparisons with observational constraints as well as with some of the most widely used existing models in the literature. The evolutionary tracks and isochrones can be downloaded from the project website at this http URL

1,127 citations

01 Jan 2008
TL;DR: By J. Biggs and C. Tang, Maidenhead, England; Open University Press, 2007.
Abstract: by J. Biggs and C. Tang, Maidenhead, England, Open University Press, 2007, 360 pp., £29.99, ISBN-13: 978-0-335-22126-4

938 citations