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Mahmood Ameen Abdulla

Bio: Mahmood Ameen Abdulla is an academic researcher from University of Malaya. The author has contributed to research in topics: Gastric mucosa & Apoptosis. The author has an hindex of 40, co-authored 191 publications receiving 5399 citations.


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Mahmood Ameen Abdulla1, Ikhlak Ahmed2, Anunchai Assawamakin3, Anunchai Assawamakin4, Jong Bhak5, Samir K. Brahmachari2, Gayvelline C. Calacal6, Amit Kumar Chaurasia2, Chien-Hsiun Chen7, Jieming Chen8, Yuan-Tsong Chen7, Jiayou Chu9, Eva Maria Cutiongco-de la Paz6, Maria Corazon A. De Ungria6, Frederick C. Delfin6, Juli Edo1, Suthat Fuchareon3, Ho Ghang5, Takashi Gojobori10, Junsong Han, Sheng Feng Ho7, Boon Peng Hoh11, Wei Huang12, Hidetoshi Inoko13, Pankaj Jha2, Timothy A. Jinam1, Li Jin14, Jongsun Jung, Daoroong Kangwanpong15, Jatupol Kampuansai15, Giulia C. Kennedy16, Preeti Khurana2, Hyung Lae Kim, Kwangjoong Kim, Sangsoo Kim17, Woo Yeon Kim5, Kuchan Kimm18, Ryosuke Kimura19, Tomohiro Koike, Supasak Kulawonganunchai4, Vikrant Kumar8, Poh San Lai20, Jong-Young Lee, Sunghoon Lee5, Edison T. Liu8, Partha P. Majumder21, Kiran Kumar Mandapati2, Sangkot Marzuki22, Wayne Mitchell8, Wayne Mitchell23, Mitali Mukerji2, Kenji Naritomi24, Chumpol Ngamphiw4, Norio Niikawa25, Nao Nishida19, Bermseok Oh, Sangho Oh5, Jun Ohashi19, Akira Oka13, Rick Twee-Hee Ong8, Carmencita Padilla6, Prasit Palittapongarnpim4, Henry B. Perdigon6, Maude E. Phipps26, Maude E. Phipps1, Eileen Png8, Yoshiyuki Sakaki, Jazelyn M. Salvador6, Yuliana Sandraling22, Vinod Scaria2, Mark Seielstad8, Mohd Ros Sidek11, Amit Sinha2, Metawee Srikummool15, Herawati Sudoyo22, Sumio Sugano19, Helena Suryadi22, Yoshiyuki Suzuki, Kristina A. Tabbada6, Adrian Tan8, Katsushi Tokunaga19, Sissades Tongsima4, Lilian P. Villamor6, Eric Wang16, Ying Wang12, Haifeng Wang12, Jer-Yuarn Wu7, Huasheng Xiao, Shuhua Xu, Jin Ok Yang5, Yin Yao Shugart27, Hyang Sook Yoo5, Wentao Yuan12, Guoping Zhao12, Bin Alwi Zilfalil11 
11 Dec 2009-Science
TL;DR: The results suggest that there may have been a single major migration of people into Asia and a subsequent south-to-north migration across the continent, and that genetic ancestry is strongly correlated with linguistic affiliations as well as geography.
Abstract: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

545 citations

Journal ArticleDOI
TL;DR: The present work reviews recent studies on the central and potential pharmacological principles as well as the preclinical applications of the α -mangostin.

165 citations

Journal ArticleDOI
TL;DR: Although traditionally aqueous extracts are used, it is determined that ethanol extracts usually achieved better activity in the assays, and exhibited a strong correlation between antioxidant activity and the total phenol contents.
Abstract: Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts The findings exhibited a strong correlation between antioxidant activity and the total phenol contents In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu) Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays

164 citations

Journal ArticleDOI
TL;DR: The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved.
Abstract: Hepatology research has focused on developing traditional therapies as pharmacological medicines to treat liver cirrhosis. Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats. The hepatoprotective effect of CLRE was measured in a rat model of thioacetamide-induced liver cirrhosis over 8 weeks. Hepatic cytochrome P450 2E1 and serum levels of TGF-β1 and TNF-α were evaluated. Oxidative stress was measured by malondialdehyde, urinary 8-hydroxyguanosine and nitrotyrosine levels. The protective activity of CLRE free-radical scavenging mechanisms were evaluated through antioxidant enzymes. Protein expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in animal blood sera was studied and confirmed by immunohistochemistry of Bax, Bcl2 proteins and proliferating cell nuclear antigen. Histopathology, immunohistochemistry and liver biochemistry were significantly lower in the Curcuma longa-treated groups compared with controls. CLRE induced apoptosis, inhibited hepatocytes proliferation but had no effect on hepatic CYP2E1 levels. The progression of liver cirrhosis could be inhibited by the antioxidant and anti-inflammatory activities of CLRE and the normal status of the liver could be preserved.

142 citations

Journal ArticleDOI
28 May 2013-PLOS ONE
TL;DR: Treatment with the extract led to the upregulation of heat-shock protein 70 (HSP70) and the downregulation of the pro-apoptotic protein BAX and significant increases in the levels of the antioxidant defense enzymes glutathione (GSH) and superoxide dismutase (SOD) in the gastric mucosal homogenate were observed, whereas that of a lipid peroxidation marker (MDA) was significantly decreased.
Abstract: Background: The current study was carried out to examine the gastroprotective effects of Parkia speciosa against ethanolinduced gastric mucosa injury in rats. Methodology/Principal Findings: Sprague Dawley rats were separated into 7 groups. Groups 1–2 were orally challenged with carboxymethylcellulose (CMC); group 3 received 20 mg/kg omeprazole and groups 4–7 received 50, 100, 200 and 400 mg/kg of ethanolic leaf extract, respectively. After 1 h, CMC or absolute ethanol was given orally to groups 2–7. The rats were sacrificed after 1 h. Then, the injuries to the gastric mucosa were estimated through assessment of the gastric wall mucus, the gross appearance of ulcer areas, histology, immunohistochemistry and enzymatic assays. Group 2 exhibited significant mucosal injuries, with reduced gastric wall mucus and severe damage to the gastric mucosa, whereas reductions in mucosal injury were observed for groups 4–7. Groups 3–7 demonstrated a reversal in the decrease in Periodic acid-Schiff (PAS) staining induced by ethanol. No symptoms of toxicity or death were observed during the acute toxicity tests. Conclusion: Treatment with the extract led to the upregulation of heat-shock protein 70 (HSP70) and the downregulation of the pro-apoptotic protein BAX. Significant increases in the levels of the antioxidant defense enzymes glutathione (GSH) and superoxide dismutase (SOD) in the gastric mucosal homogenate were observed, whereas that of a lipid peroxidation marker (MDA) was significantly decreased. Significance was defined as p,0.05 compared to the ulcer control group (Group 2). Citation: Al Batran R, Al-Bayaty F, Jamil Al-Obaidi MM, Abdualkader AM, Hadi HA, et al. (2013) In Vivo Antioxidant and Antiulcer Activity of Parkia speciosa

124 citations


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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Journal ArticleDOI
TL;DR: A unified analytic framework to discover and genotype variation among multiple samples simultaneously that achieves sensitive and specific results across five sequencing technologies and three distinct, canonical experimental designs is presented.
Abstract: Recent advances in sequencing technology make it possible to comprehensively catalogue genetic variation in population samples, creating a foundation for understanding human disease, ancestry and evolution. The amounts of raw data produced are prodigious and many computational steps are required to translate this output into high-quality variant calls. We present a unified analytic framework to discover and genotype variation among multiple samples simultaneously that achieves sensitive and specific results across five sequencing technologies and three distinct, canonical experimental designs. Our process includes (1) initial read mapping; (2) local realignment around indels; (3) base quality score recalibration; (4) SNP discovery and genotyping to find all potential variants; and (5) machine learning to separate true segregating variation from machine artifacts common to next-generation sequencing technologies. We discuss the application of these tools, instantiated in the Genome Analysis Toolkit (GATK), to deep whole-genome, whole-exome capture, and multi-sample low-pass (~4×) 1000 Genomes Project datasets.

10,056 citations

Journal Article
TL;DR: This volume is keyed to high resolution electron microscopy, which is a sophisticated form of structural analysis, but really morphology in a modern guise, the physical and mechanical background of the instrument and its ancillary tools are simply and well presented.
Abstract: I read this book the same weekend that the Packers took on the Rams, and the experience of the latter event, obviously, colored my judgment. Although I abhor anything that smacks of being a handbook (like, \"How to Earn a Merit Badge in Neurosurgery\") because too many volumes in biomedical science already evince a boyscout-like approach, I must confess that parts of this volume are fast, scholarly, and significant, with certain reservations. I like parts of this well-illustrated book because Dr. Sj6strand, without so stating, develops certain subjects on technique in relation to the acquisition of judgment and sophistication. And this is important! So, given that the author (like all of us) is somewhat deficient in some areas, and biased in others, the book is still valuable if the uninitiated reader swallows it in a general fashion, realizing full well that what will be required from the reader is a modulation to fit his vision, propreception, adaptation and response, and the kind of problem he is undertaking. A major deficiency of this book is revealed by comparison of its use of physics and of chemistry to provide understanding and background for the application of high resolution electron microscopy to problems in biology. Since the volume is keyed to high resolution electron microscopy, which is a sophisticated form of structural analysis, but really morphology in a modern guise, the physical and mechanical background of The instrument and its ancillary tools are simply and well presented. The potential use of chemical or cytochemical information as it relates to biological fine structure , however, is quite deficient. I wonder when even sophisticated morphol-ogists will consider fixation a reaction and not a technique; only then will the fundamentals become self-evident and predictable and this sine qua flon will become less mystical. Staining reactions (the most inadequate chapter) ought to be something more than a technique to selectively enhance contrast of morphological elements; it ought to give the structural addresses of some of the chemical residents of cell components. Is it pertinent that auto-radiography gets singled out for more complete coverage than other significant aspects of cytochemistry by a high resolution microscopist, when it has a built-in minimal error of 1,000 A in standard practice? I don't mean to blind-side (in strict football terminology) Dr. Sj6strand's efforts for what is \"routinely used in our laboratory\"; what is done is usually well done. It's just that …

3,197 citations

01 Jan 1999
TL;DR: Caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases as discussed by the authors, and they play critical roles in initiation and execution of this process.
Abstract: ■ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli. Studies performed over the past 10 years have demonstrated that proteases play critical roles in initiation and execution of this process. The caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases. Caspases are synthesized as relatively inactive zymogens that become activated by scaffold-mediated transactivation or by cleavage via upstream proteases in an intracellular cascade. Regulation of caspase activation and activity occurs at several different levels: ( a) Zymogen gene transcription is regulated; ( b) antiapoptotic members of the Bcl-2 family and other cellular polypeptides block proximity-induced activation of certain procaspases; and ( c) certain cellular inhibitor of apoptosis proteins (cIAPs) can bind to and inhibit active caspases. Once activated, caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair machinery, and a number of protein kinases. Collectively, these scissions disrupt survival pathways and disassemble important architectural components of the cell, contributing to the stereotypic morphological and biochemical changes that characterize apoptotic cell death.

2,685 citations