Mai thi Quynh Le

TL;DR: In this article, the authors characterized in vitro and in vivo properties of two pairs of oseltaimivir-sensitive and -resistant (possessing the NA H274Y substitution) 2009 H1N1 pandemic viruses isolated in different parts of the world.

TL;DR: It is found that the residue at position 134 of HA alters the receptor-binding property of the virus, as measured by viral elution from erythrocytes, and both of the residues at positions 200 and 205 of NS1 contributed to enhanced type I interferon (IFN) antagonistic activity.

TL;DR: It is shown that the monoclonal antibody C179, which recognizes a neutralizing epitope common among H1, H2, H5, and H6 hemagglutinins (HAs), protected mice from a lethal challenge with various H5N1 and pandemic 2009 viruses when administered either intraperitoneally or intranasally.

TL;DR: The results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.

TL;DR: In this paper, the authors measured various cytokines produced by primary human macrophages infected with H5N1, pandemic H1N1 or seasonal influenza viruses and found that many cytokines were produced at higher levels on infection with the H5Ns1 strains tested compared with seasonal influenza virus.