M
Mairead Duke
Publications - 2
Citations - 1613
Mairead Duke is an academic researcher. The author has contributed to research in topics: Genetically modified mouse & Amyloid precursor protein. The author has an hindex of 2, co-authored 2 publications receiving 1542 citations.
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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Christine Sturchler-Pierrat,Dorothee Abramowski,Mairead Duke,Karl-Heinz Wiederhold,Claudia Mistl,Sabin Rothacher,Birgit Ledermann,Kurt Bürki,Peter Frey,Paolo Paganetti,Caroline Waridel,Michael E. Calhoun,Mathias Jucker,Alphonse Probst,Matthias Staufenbiel,Bernd Sommer +15 more
TL;DR: These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease.
Journal ArticleDOI
Expression of APP in transgenic mice: a comparison of neuron-specific promoters.
Kerstin Andrä,Dorothee Abramowski,Mairead Duke,Alphonse Probst,Karl-Heinz Wiederhold,Kurt Bürki,Michel Goedert,Bernd Sommer,Matthias Staufenbiel +8 more
TL;DR: Although the initial histological examinations did not reveal any alterations characteristic of AD, further studied will be required, variable reactivity of human APP in cell bodies was shown by immunocytochemistry and protein levels paralleled mRNA levels reaching or exceeding the amount of endogenous APP.