M
Makoto Mark Taketo
Researcher at Kyoto University
Publications - 436
Citations - 51250
Makoto Mark Taketo is an academic researcher from Kyoto University. The author has contributed to research in topics: Wnt signaling pathway & Cellular differentiation. The author has an hindex of 119, co-authored 419 publications receiving 46995 citations. Previous affiliations of Makoto Mark Taketo include Merck & Co. & University of Tokyo.
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Journal ArticleDOI
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Masanobu Oshima,Joseph E. Dinchuk,Stacia Kargman,Hiroko Oshima,Bruno C. Hancock,Elizabeth Kwong,James M. Trzaskos,Jilly F. Evans,Makoto Mark Taketo,Makoto Mark Taketo +9 more
TL;DR: Results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COx-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer.
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Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene
Naomoto Harada,Yoshitaka Tamai,Tomo O. Ishikawa,Brian C. Sauer,Brian C. Sauer,Kazuaki Takaku,Masanobu Oshima,Makoto Mark Taketo +7 more
TL;DR: Experimental genetic evidence is presented that activation of the Wnt signaling pathway can cause intestinal and colonic tumors.
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Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
TL;DR: It is shown by conditionally deleting beta-catenin in limb and head mesenchyme that beta- catenin is required for osteoblast lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes.
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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Sarah Schwitalla,Alexander A. Fingerle,Patrizia Cammareri,Tim Nebelsiek,Serkan Ismail Göktuna,Paul Ziegler,Özge Canli,Jarom Heijmans,David J. Huels,Guenievre Moreaux,Rudolf A. Rupec,Markus Gerhard,Roland M. Schmid,Nick Barker,Hans Clevers,Roland Lang,Jens Neumann,Thomas Kirchner,Makoto Mark Taketo,Gijs R. van den Brink,Owen J. Sansom,Melek C. Arkan,Florian R. Greten +22 more
TL;DR: This work demonstrates that NF-κB modulates Wnt signaling and shows that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion and highlights the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo.
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Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part II)
TL;DR: Accumulating evidence indicates that NSAIDs can reduce the incidence of colorectal cancers in human and experimental animals and can reduced the number and size of polyps in patients with familial adenomatous polyposis.