Makoto Sasaki

TL;DR: A double-transfected Madin-Darby canine kidney (MDCK II) cell monolayer is established, which expresses both OATP2 and MRP2 on basal and apical membranes, respectively, and may be used to analyze the hepatic vectorial transport of organic anions and to screen the transport profiles of new drug candidates.

TL;DR: It is shown that Aes (or Grg5) gene functions as an endogenous metastasis suppressor and inhibition of Notch signaling can be a promising strategy for prevention and treatment of colon cancer metastasis.

TL;DR: Two kinds of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, CER and PRA, were also substrates of all these efflux transporters, and the rank order of the efflux clearance of PRA mediated by each transporter was the same as that of EG, whereas the contribution of MDR1 to theefflux of CER was relatively greater than for PRA.

TL;DR: A mechanism and control method of a mobile exoskeleton robot for 3DOF upper-limb motion assist (shoulder vertical and horizontal flexion/extension, and elbow flexion-extension motion assist) and an obstacle avoidance algorithm is applied to prevent accidental collision between the user's upper- Limb and the robot frame is proposed.

TL;DR: The first total synthesis of (-)-gambierol (1), a marine polycyclic ether toxin, has been achieved as discussed by the authors, which includes a convergent union of the ABC and EFGH ring fragments via a developed B-alkyl Suzuki-Miyaura cross-coupling strategy leading to the octacyclic polyether core 4 and a late-stage introduction of the sensitive triene side chain by use of Pd(PPh(3))(4)/CuCl/LiCl-promoted Stille coupling.