M
Malachi Griffith
Researcher at Washington University in St. Louis
Publications - 205
Citations - 18642
Malachi Griffith is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 52, co-authored 152 publications receiving 15330 citations. Previous affiliations of Malachi Griffith include University of British Columbia & University of Manitoba.
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Journal ArticleDOI
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah,Andrew Roth,Rodrigo Goya,Arusha Oloumi,Gavin Ha,Yongjun Zhao,Gulisa Turashvili,Jiarui Ding,Kane Tse,Gholamreza Haffari,Ali Bashashati,Leah M Prentice,Jaswinder Khattra,Angela Burleigh,Damian Yap,Virginie Bernard,Andrew McPherson,Karey Shumansky,Anamaria Crisan,Ryan Giuliany,Alireza Heravi-Moussavi,Jamie Rosner,Daniel Lai,Inanc Birol,Richard Varhol,Angela Tam,Noreen Dhalla,Thomas Zeng,Kevin C. Ma,Simon K. Chan,Malachi Griffith,Annie Moradian,S.-W. Grace Cheng,Gregg B. Morin,Peter H. Watson,Karen A. Gelmon,Stephen Chia,Suet-Feung Chin,Christina Curtis,Christina Curtis,Oscar M. Rueda,Paul D.P. Pharoah,Sambasivarao Damaraju,John R. Mackey,Kelly Hoon,Timothy T. Harkins,Vasisht Tadigotla,Mahvash Sigaroudinia,Philippe Gascard,Thea D. Tlsty,Joseph F. Costello,Irmtraud M. Meyer,Connie J. Eaves,Wyeth W. Wasserman,Steven J.M. Jones,Steven J.M. Jones,David G. Huntsman,David G. Huntsman,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio +61 more
TL;DR: It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
Journal ArticleDOI
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin,Maria Mendez-Lago,Andrew J. Mungall,Rodrigo Goya,Karen Mungall,Richard Corbett,Nathalie A. Johnson,Tesa M. Severson,Readman Chiu,Matthew A. Field,Shaun D. Jackman,Martin Krzywinski,David W. Scott,Diane L. Trinh,Jessica Tamura-Wells,Sa Li,Marlo Firme,Sanja Rogic,Malachi Griffith,Susanna Chan,Oleksandr Yakovenko,Irmtraud M. Meyer,Eric Y. Zhao,Duane E. Smailus,Michelle Moksa,Suganthi Chittaranjan,Lisa M. Rimsza,Angela Brooks-Wilson,Angela Brooks-Wilson,John J. Spinelli,Susana Ben-Neriah,Barbara Meissner,Bruce Woolcock,Merrill Boyle,Helen McDonald,Angela Tam,Yongjun Zhao,Allen Delaney,Thomas Zeng,Kane Tse,Yaron S.N. Butterfield,Inanc Birol,Robert A. Holt,Jacqueline E. Schein,Douglas E. Horsman,Richard A. Moore,Steven J.M. Jones,Joseph M. Connors,Martin Hirst,Randy D. Gascoyne,Marco A. Marra +50 more
TL;DR: Genes with roles in histone modification were frequent targets of somatic mutation and suggest a previously unappreciated disruption of chromatin biology in lymphomagenesis in NHLs.
Journal ArticleDOI
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.
Ryan D. Morin,Michael D O'Connor,Malachi Griffith,Florian Kuchenbauer,Allen Delaney,Anna-Liisa Prabhu,Yongjun Zhao,Helen McDonald,Thomas Zeng,Martin Hirst,Connie J. Eaves,Marco A. Marra +11 more
TL;DR: Application of this approach to RNA from human embryonic stem cells obtained before and after their differentiation into embryoid bodies revealed the sequences and expression levels of 334 known plus 104 novel miRNA genes, representing the deepest miRNA sampling to date.
Journal ArticleDOI
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Ramaswamy Govindan,Li Ding,Malachi Griffith,Janakiraman Subramanian,Nathan D. Dees,Krishna L. Kanchi,Christopher G. Maher,Robert S. Fulton,Lucinda Fulton,John W. Wallis,Ken Chen,Jason Walker,Sandra McDonald,Ron Bose,David M. Ornitz,Dong Hai Xiong,Ming You,David J. Dooling,Mark A. Watson,Elaine R. Mardis,Richard K. Wilson +20 more
TL;DR: Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs, including ROS1 and ALK, as well as novel metabolic enzymes.
Journal ArticleDOI
De novo assembly and analysis of RNA-seq data
Gordon Robertson,Jacqueline E. Schein,Readman Chiu,Richard Corbett,Matthew A. Field,Shaun D. Jackman,Karen Mungall,Sam Lee,Hisanaga Mark Okada,Jenny Q. Qian,Malachi Griffith,Anthony Raymond,Nina Thiessen,Timothee Cezard,Timothee Cezard,Yaron S. Butterfield,Richard Newsome,Simon K. Chan,Rong She,Richard Varhol,Baljit Kamoh,Anna Liisa Prabhu,Angela Tam,Yongjun Zhao,Richard A. Moore,Martin Hirst,Marco A. Marra,Marco A. Marra,Steven J.M. Jones,Steven J.M. Jones,Pamela A. Hoodless,Pamela A. Hoodless,Inanc Birol +32 more
TL;DR: Trans-ABySS, a de novo short-read transcriptome assembly and analysis pipeline that addresses variation in local read densities by assembling read substrings with varying stringencies and then merging the resulting contigs before analysis, achieves high sensitivity and specificity relative to reference-based assembly methods.