M
Malcolm F. White
Researcher at University of St Andrews
Publications - 182
Citations - 12843
Malcolm F. White is an academic researcher from University of St Andrews. The author has contributed to research in topics: DNA & CRISPR. The author has an hindex of 55, co-authored 172 publications receiving 10762 citations. Previous affiliations of Malcolm F. White include QIMR Berghofer Medical Research Institute & University of Glasgow.
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Journal ArticleDOI
An updated evolutionary classification of CRISPR–Cas systems
Kira S. Makarova,Yuri I. Wolf,Omer S. Alkhnbashi,Fabrizio Costa,Shiraz A. Shah,Sita J. Saunders,Rodolphe Barrangou,Stan J. J. Brouns,Emmanuelle Charpentier,Daniel H. Haft,Philippe Horvath,Sylvain Moineau,Francisco J. M. Mojica,Rebecca M. Terns,Michael P. Terns,Malcolm F. White,Alexander F. Yakunin,Roger A. Garrett,John van der Oost,Rolf Backofen,Eugene V. Koonin +20 more
TL;DR: An approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR–cas loci into distinct classes, types and subtypes is presented.
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Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
Kira S. Makarova,Yuri I. Wolf,Jaime Iranzo,Sergey Shmakov,Omer S. Alkhnbashi,Stan J. J. Brouns,Emmanuelle Charpentier,David R. Cheng,Daniel H. Haft,Philippe Horvath,Sylvain Moineau,Francisco J. M. Mojica,David Scott,Shiraz A. Shah,Virginijus Siksnys,Michael P. Terns,Česlovas Venclovas,Malcolm F. White,Alexander F. Yakunin,Alexander F. Yakunin,Winston X. Yan,Feng Zhang,Roger A. Garrett,Rolf Backofen,John van der Oost,Rodolphe Barrangou,Eugene V. Koonin +26 more
TL;DR: An updated evolutionary classification of CRISPR–Cas systems and cas genes is provided, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015, which includes 2 classes, 6 types and 33 subtypes.
Journal ArticleDOI
Nucleosome mobilization catalysed by the yeast SWI/SNF complex
Iestyn Whitehouse,Andrew Flaus,Bradley R. Cairns,Malcolm F. White,Jerry L. Workman,Tom Owen-Hughes +5 more
TL;DR: It is concluded that SWI/SNF catalyses the redistribution of nucleosomes along DNA in cis, which may represent a general mechanism by which ATP-dependent chromatin remodelling occurs.
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The DNA Repair Helicases XPD and FancJ Have Essential Iron-Sulfur Domains
TL;DR: It is demonstrated that both XPD and FancJ proteins have a conserved domain near the N terminus that includes an iron-sulfur (Fe-S) cluster, which is essential for the helicase activity of XPD.
Journal ArticleDOI
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity
Jing Zhang,Christophe Rouillon,Melina Kerou,Judith Reeks,Kim Brügger,Shirley Graham,Julia Reimann,Giuseppe Cannone,Huanting Liu,Sonja-Verena Albers,James H. Naismith,Laura Spagnolo,Malcolm F. White +12 more
TL;DR: The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISpr RNA, derived from invading viruses and incorporated into ribonucleoprotein complexes with CRISPR-associated proteins, to target and degrade viral DNA or RNA on subsequent infection.