M
Mallika Imwong
Researcher at Mahidol University
Publications - 224
Citations - 18003
Mallika Imwong is an academic researcher from Mahidol University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 56, co-authored 205 publications receiving 15410 citations. Previous affiliations of Mallika Imwong include Thailand National Science and Technology Development Agency & University of Oxford.
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Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Magnus Manske,Magnus Manske,Olivo Miotto,Olivo Miotto,Susana Campino,Susana Campino,Sarah Auburn,Sarah Auburn,Sarah Auburn,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Gareth Maslen,Gareth Maslen,John O'Brien,John O'Brien,Abdoulaye A. Djimde,Ogobara K. Doumbo,Issaka Zongo,Jean-Bosco Ouédraogo,Pascal Michon,Ivo Mueller,Peter Siba,Alexis Nzila,Steffen Borrmann,Steven M. Kiara,Kevin Marsh,Hongying Jiang,Xin-zhuan Su,Chanaki Amaratunga,Rick M. Fairhurst,Duong Socheat,François Nosten,François Nosten,Mallika Imwong,Nicholas J. White,Nicholas J. White,Mandy Sanders,Elisa Anastasi,Dan Alcock,Eleanor Drury,Samuel O. Oyola,Michael A. Quail,Daniel J. Turner,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Dushyanth Jyothi,Dushyanth Jyothi,Lucas Amenga-Etego,Lucas Amenga-Etego,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Colin J. Sutherland,Cally Roper,Valentina D. Mangano,David Modiano,John C. Tan,Michael T. Ferdig,Alfred Amambua-Ngwa,David J. Conway,Shannon Takala-Harrison,Christopher V. Plowe,Julian C. Rayner,Kirk A. Rockett,Kirk A. Rockett,Kirk A. Rockett,Taane G. Clark,Taane G. Clark,Taane G. Clark,Chris I. Newbold,Chris I. Newbold,Matthew Berriman,Bronwyn MacInnis,Bronwyn MacInnis,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +78 more
TL;DR: Methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture are described.
Journal ArticleDOI
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Olivo Miotto,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Magnus Manske,Bronwyn MacInnis,Susana Campino,K.A. Rockett,K.A. Rockett,K.A. Rockett,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Socheat Duong,Chea Nguon,Char Meng Chuor,David S. Saunders,Youry Se,Chantap Lon,Mark M. Fukuda,Lucas Amenga-Etego,Lucas Amenga-Etego,Abraham Hodgson,Victor Asoala,Mallika Imwong,Shannon Takala-Harrison,François Nosten,François Nosten,Xin-zhuan Su,Pascal Ringwald,Frédéric Ariey,Christiane Dolecek,Tran Tinh Hien,Maciej F. Boni,Cao Quang Thai,Alfred Amambua-Ngwa,David J. Conway,David J. Conway,Abdoulaye A. Djimde,Ogobara K. Doumbo,Issaka Zongo,Jean-Bosco Ouédraogo,Daniel Alcock,Eleanor Drury,Sarah Auburn,Oliver O Koch,Mandy Sanders,Christina Hubbart,Gareth Maslen,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Dushyanth Jyothi,Alistair Miles,John O'Brien,Chris Gamble,Samuel O. Oyola,Julian C. Rayner,Chris I. Newbold,Chris I. Newbold,Chris I. Newbold,Matthew Berriman,Chris C. A. Spencer,Gilean McVean,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,Delia Bethell,Arjen M. Dondorp,Arjen M. Dondorp,Christopher V. Plowe,Rick M. Fairhurst,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +76 more
TL;DR: An analysis of genome variation in 825 P. falciparum samples from Asia and Africa is described that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia, and a catalog of SNPs that show high levels of differentiation in the art Artemisinin-resistant subpopulations are provided.