M
Man Hw
Researcher at Celgene
Publications - 3
Citations - 923
Man Hw is an academic researcher from Celgene. The author has contributed to research in topics: Apremilast & Biological activity. The author has an hindex of 3, co-authored 3 publications receiving 826 citations.
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Journal ArticleDOI
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Peter H. Schafer,Anastasia Parton,Anita Gandhi,Lori Capone,Mary Adams,Lei Wu,Justin B. Bartlett,Loveland Ma,Amos Gilhar,Cheung Yf,George S. Baillie,Houslay,Man Hw,G. W. Muller,D. I. Stirling +14 more
TL;DR: The inhibitory effects of apremilast on pro‐inflammatory responses of human primary peripheral blood mononuclear cells, polymorphonuclear Cells, natural killer cells and epidermal keratinocytes were explored in vitro, and in a preclinical model of psoriasis.
Journal ArticleDOI
Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects
Keith Dredge,Marriott Jb,Macdonald Cd,Man Hw,Chen R,G W Muller,David I. Stirling,Angus G. Dalgleish +7 more
TL;DR: This study assessed the anti-angiogenic activity of compounds from both IMiD™ and SelCID™ classes of analogues using a novel in vitro multicellular human assay system and the established rat aorta assay.
Journal ArticleDOI
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.
Peter H. Schafer,Anastasia Parton,Lori Capone,Dorota Cedzik,Helen Brady,Jilly F. Evans,Man Hw,G.W. Muller,D.I. Stirling,Rajesh Chopra +9 more
TL;DR: The pharmacological effects of apremilast are consistent with those of a targeted PDE4 inhibitor, with selective effects on innate immune responses and a wide therapeutic index compared to its gastrointestinal side effects.