Man J. Livingston

TL;DR: The authors summarize the basics of autophagy and the signalling pathways involved in its regulation, and examine the multiple roles of autophile in kidney cells, from its involvement in kidney maintenance and responses to injury, to its potential contribution to glomerular and tubulointerstitial disease.

TL;DR: It is suggested that persistent activation of autophagy in kidney proximal tubules promotes renal interstitial fibrosis during UUO.

TL;DR: This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of Autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease.

TL;DR: IPC induced autophagy in renal tubular cells in mice and suppressed subsequent renal ischemia-reperfusion injury (IRI), suggesting that IPC may protect kidneys by activating mitophagy, and in vitro IPC increased mitophagosome formation and promoted the clearance of damaged mitochondria during subsequent CCCP treatment.

TL;DR: Results suggest that cilia and autophagy regulate reciprocally through the MTOR signaling pathway and ubiquitin-proteasome system.