Author
Manfred Donike
Bio: Manfred Donike is an academic researcher from University of Cologne. The author has contributed to research in topics: Amine gas treating & Organic base. The author has an hindex of 8, co-authored 9 publications receiving 373 citations.
Papers
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118 citations
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TL;DR: In this paper, N-Methyl-bis and bis (trifluoroacetamide) are used as reagents for selective acylation of amine functions in the presence of hydroxyl or carboxyl groups.
80 citations
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TL;DR: In this article, the thermodynamic and kinetic aspects of the trimethylsilylation and N-trifluoroacetyl-O-trimethyl-silyl-phenolalkylamines are discussed.
60 citations
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36 citations
Cited by
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TL;DR: Derivatization reactions for the determination of amines by GC are reviewed with respect to reactivity, selectivity and sensitivity.
285 citations
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TL;DR: The mechanism of the silylation reaction and the methods of synthesis and properties of silylating agents are discussed in this paper, together with the Silylation of various classes of compounds in relation to the most characteristic substances.
Abstract: The mechanism of the silylation reaction and the methods of synthesis and properties of silylating agents are discussed together with the silylation of various classes of compounds in relation to the most characteristic substances. The bibliography includes 186 references.
263 citations
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TL;DR: Main derivatization procedures for opiates, cocaine, cannabis, amphetamines, benzodiazepines and LSD have been reviewed and papers describing the analyses of drugs of abuse in matrixes other than blood, such as hair or sweat, have received special attention.
237 citations
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TL;DR: Advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds are described.
Abstract: This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular analyses are summarised.
213 citations