M
Manfred Fliegauf
Researcher at University of Freiburg
Publications - 64
Citations - 7700
Manfred Fliegauf is an academic researcher from University of Freiburg. The author has contributed to research in topics: Cilium & Common variable immunodeficiency. The author has an hindex of 33, co-authored 61 publications receiving 6776 citations. Previous affiliations of Manfred Fliegauf include Boston Children's Hospital & University of Münster.
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When cilia go bad: cilia defects and ciliopathies
TL;DR: Cilia — tiny hair-like organelles attached to the cell surface — are located on almost all polarized cell types of the human body and have been adapted as versatile tools for various cellular functions, explaining why cilia-related disorders can affect many organ systems.
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Erratum: When cilia go bad: cilia defects and ciliopathies
TL;DR: Cilia--tiny hair-like organelles attached to the cell surface--are located on almost all polarized cell types of the human body and have been adapted as versatile tools for various cellular functions, explaining why cilia-related disorders can affect many organ systems.
Journal ArticleDOI
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
Ditsa Levanon,David Bettoun,Catherine Harris-Cerruti,Eilon Woolf,Varda Negreanu,Raya Eilam,Yael Bernstein,Dalia Goldenberg,Cuiying Xiao,Manfred Fliegauf,E. Kremer,Florian Otto,Ori Brenner,Aharon Lev-Tov,Yoram Groner +14 more
TL;DR: It is shown that Runx3‐deficient mice develop severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneurons, and the underlying cause is a loss of DRG proprioceptive neurons.
Journal ArticleDOI
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
Heike Olbrich,Manfred Fliegauf,Julia Hoefele,Andreas Kispert,Edgar A. Otto,Andreas Volz,Matthias T.F. Wolf,Gürsel Sasmaz,Ute Trauer,Richard Reinhardt,Ralf Sudbrak,Corinne Antignac,Norbert Gretz,Gerd Walz,Bernhard Schermer,Thomas Benzing,Friedhelm Hildebrandt,Heymut Omran +17 more
TL;DR: The identification of NPHP3, encoding a novel 1,330-amino acid protein that interacts with nephrocystin, and it is shown that the mouse ortholog Nphp3 is expressed in the node, kidney tubules, retina, respiratory epithelium, liver, biliary tract and neural tissues.
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Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins
Heymut Omran,Daisuke Kobayashi,Daisuke Kobayashi,Heike Olbrich,Tatsuya Tsukahara,Niki T. Loges,Haruo Hagiwara,Qi Zhang,Qi Zhang,Gerard Leblond,Eileen T. O'Toole,Chikako Hara,Hideaki Mizuno,Hiroyuki Kawano,Manfred Fliegauf,Toshiki Yagi,Toshiki Yagi,Sumito Koshida,Atsushi Miyawaki,Hanswalter Zentgraf,H. Seithe,Richard Reinhardt,Yoshinori Watanabe,Ritsu Kamiya,David R. G. Mitchell,Hiroyuki Takeda +25 more
TL;DR: Biochemical and immunohistochemical studies show that Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.