Manolis Kellis

TL;DR: Examination of regions of the human genome that did not show conservation among mammals and found evidence for a human lineage-specific constraint spanning approximately 4% of the genome that is biochemically active but not directly associated with genes, suggests continued turnover in regulatory regions.

TL;DR: In this paper, a general method for inferring direct effects from an observed correlation matrix containing both direct and indirect effects is presented, which is the inverse of network convolution, and introduces an algorithm that removes the combined effect of all indirect paths of arbitrary length in a closed-form solution by exploiting eigendecomposition and infinite-series sums.

TL;DR: A general methodology for the comparative identification of functional motif instances across many related species is developed, using a phylogenetic framework that accounts for the evolutionary relationships between species, allows for motif movements, and is robust against missing data due to artifacts in sequencing, assembly, or alignment.

TL;DR: In this paper, a broad range of transcribed and regulatory nonconserved elements show decreased human diversity, suggesting lineage-specific purifying selection, while conserved elements lacking activity show increased human diversity.

TL;DR: Condensation of N-protein is RNA sequence and structure specific, sensitive to human body temperature, and manipulatable with small molecules, and presents a screenable process for identifying antiviral compounds effective against SARS-CoV-2.