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Manolis Kellis

Researcher at Massachusetts Institute of Technology

Publications -  448
Citations -  132627

Manolis Kellis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 128, co-authored 405 publications receiving 112181 citations. Previous affiliations of Manolis Kellis include Broad Institute & Epigenomics AG.

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Evolution of genes and genomes on the Drosophila phylogeny.

Andrew G. Clark, +429 more
- 08 Nov 2007 - 
TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.
Journal Article

Histone Modifications at Human Enhancers Reflect Global Cell-Type-Specific Gene Expression

Nathaniel D. Heintzman, +20 more
- 01 Mar 2009 - 
TL;DR: In this article, a chromatin-immunoprecipitation-based microarray method (ChIP-chip) was used to locate promoters, enhancers and insulators in the human genome and investigate their roles in cell-type specific gene expression.
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Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Xiaohui Xie, +9 more
- 17 Mar 2005 - 
TL;DR: In this article, a comparative analysis of the human, mouse, rat and dog genomes is presented to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs).
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Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype

Olivier Jaillon, +62 more
- 21 Oct 2004 - 
TL;DR: Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish, and reconstructs much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
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Sequencing and comparison of yeast species to identify genes and regulatory elements

Manolis Kellis, +4 more
- 15 May 2003 - 
TL;DR: A comparative analysis of the yeast Saccharomyces cerevisiae based on high-quality draft sequences of three related species, which inferred a putative function for most of these motifs, and provided insights into their combinatorial interactions.