Manolis Kellis

TL;DR: It is found that species at a broad range of distances are comparably effective informants for pairwise comparative gene identification, but that these are surpassed by multi-species comparisons at similar evolutionary divergence, and genes in functional categories typically considered fast-evolving can nonetheless be recovered at very high rates using comparative methods.

TL;DR: This work suggests that positional information, especially the relative spacing between transcription factor binding sites, may represent a common organizing principle of transcription control regions.

TL;DR: This work provides new software tools and demonstrates their use on a number of datasets from evolutionary genomic and cophylogenetic studies, providing the first systematic method for understanding the relationship between event costs and reconciliations.

TL;DR: A vast AE resource generated from the GTEx v8 release is presented and the utility of this resource is demonstrated, and an extension of the tool phASER is developed that allows effect sizes of cis -regulatory variants to be estimated using haplotype-level AE data.

TL;DR: The role of DNA methylation in Alzheimer's disease is explored and causal models to assess its role in the pathology of AD are examined.