Manolis Kellis

TL;DR: A next-generation sequencing approach combined with machine learning is used to screen a synthetic promoter library with 6107 designs for high-performance SPECS for potentially any cell state.

TL;DR: A novel framework to profile long-range chromatin interactions associated with AR and its collaborative transcription factor, erythroblast transformation-specific related gene (ERG), using chromatin interaction analysis by paired-end tag (ChIA-PET).

TL;DR: It is found that most differences between the readthrough repertoires of the two species arose from readthrough gain or loss in existing genes, rather than birth of new genes or gene death; that readthrough-associated RNA structures are sometimes gained or lost while readthrough persists; and that read through is under continued purifying evolutionary selection in mosquito, based on population genetic evidence.

TL;DR: This study reveals how bumblebee genes and genomes have evolved across the Bombus phylogeny and identifies variations potentially linked to key ecological and behavioral traits of these important pollinators.

TL;DR: The first single-cell dissection of schizophrenia is presented, across 500,000+ cells from 48 postmortem human prefrontal cortex samples, and a novel excitatory-neuron cell-state is discovered indicative of transcriptional resilience and enriched in schizophrenia subjects with less-perturbed transcriptional signatures.