Manolis Kellis

TL;DR: NuORFs thus expand the pool of MHC I-presented, tumor-specific peptides, targetable by immunotherapies, by detecting somatic mutations in nuORFs of cancer samples and identifiednuORFs with tumor- specific translation in melanoma, chronic lymphocytic leukemia and glioblastoma.

TL;DR: Findings reveal widespread production of non-canonical protein isoforms and unexpected complexity to the rules by which even a simple eukaryotic genome is decoded.

TL;DR: An updated map of the Drosophila melanogaster regulatory genome based on the location of 84 TRFs at various stages of development reveals a variety of genomic targeting patterns, including factors with strong preferences toward proximal promoter binding, factors that target intergenic and intronic DNA, and factors with distinct chromatin state preferences.

TL;DR: Li et al. as mentioned in this paper proposed a hierarchical hidden Markov model (diHMM) to identify domain-level states that vary in nucleosome-level state composition, spatial distribution and functionality.

TL;DR: Deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry is used to discover and interpret both single-nucleotide variants and copy number (CN) variation associated with Lp(a), and finds that LPA risk genotypes confer greater relative risk for incident atherosclerotic cardiovascular diseases compared to directly measured LP(a).