Manolis Kellis

TL;DR: ACTIONet is introduced, a comprehensive framework that combines archetypal analysis and network theory to provide a ready-to-use analytical approach for multiresolution single-cell state characterization.

TL;DR: The results demonstrate the importance of dense, rich, and high-resolution epigenomic annotations for complex trait dissection, and yield numerous new insights for understanding the molecular basis of human disease.

TL;DR: The SPLITR framework as mentioned in this paper integrates single-nucleus and bulk RNA-seq data, enabling phenotype-aware deconvolution and correcting for systematic discrepancies between bulk and single-cell data.

TL;DR: The proposed SwiSpot approach is capable of identifying the switching sequence inside a putative, complete riboswitch sequence, on the basis of pairing behaviors, which are evaluated on proper sets of configurations and is able to model the switching behavior of riboswitches whose generated ensemble covers both alternate configurations.

TL;DR: Overall, the results confirm that SINE Alu elements have contributed to the expansion of the human proteome, and this contribution appears to be stronger than might be expected over such a relatively short evolutionary timeframe.