Manoor Prakash Hande

TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.

TL;DR: It is shown that hTERT overexpression not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation, and in doing so endowing cancer cells with the ability to evade death stimuli.

TL;DR: It is demonstrated that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS, and it is shown that telomeric repeats indeed are hypersensitive to DNA replication stress.

TL;DR: It is suggested that zinc oxide nanoparticles induced significant oxidative stress-related cytotoxicity and genotoxicity in human lung fibroblasts in vitro and in D. melanogaster in vivo, indicating that nuclear factor E2-related factor 2 (Nrf2) plays important role in ZnO NPs-mediated ROS production.

TL;DR: It is proposed that human WJSC may be frozen at the same time as UCB in cord blood banks for regenerative medicine purposes.